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Åsa B. Gustafsson
Researcher at University of Montana
Publications - 104
Citations - 20495
Åsa B. Gustafsson is an academic researcher from University of Montana. The author has contributed to research in topics: Autophagy & Mitochondrion. The author has an hindex of 49, co-authored 92 publications receiving 16938 citations. Previous affiliations of Åsa B. Gustafsson include Scripps Research Institute & University of California, San Diego.
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Journal ArticleDOI
Mitophagy and heart failure.
TL;DR: Evidence suggests thatmitophagy is important for cellular homeostasis, and reduced mitophagy leads to inadequate removal of dysfunctional mitochondria, and the prospect of therapeutically targetingMitophagy to treat patients with cardiovascular disease is addressed.
Journal ArticleDOI
Pim-1 Kinase Protects Mitochondrial Integrity in Cardiomyocytes
Gwynngelle A. Borillo,Matt Mason,Pearl Quijada,Mirko Völkers,Christopher T. Cottage,Michael McGregor,Shabana Din,Kimberlee M. Fischer,Natalie Gude,Daniele Avitabile,Steven B. Barlow,Roberto Alvarez,Silvia Truffa,Ross Whittaker,Matthew S. Glassy,Åsa B. Gustafsson,Shigeki Miyamoto,Christopher C. Glembotski,Roberta A. Gottlieb,Joan Heller Brown,Mark A. Sussman +20 more
TL;DR: It is demonstrated that the cardioprotective kinase Pim-1 acts to inhibit cell death by preserving mitochondrial integrity in cardiomyocytes by antagonizing proapoptotic Bcl-2 family members that regulate the intrinsic apoptotic pathway.
Journal ArticleDOI
Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA
Smadar Yitzhaki,Chengqun Huang,Wayne Liu,Youngil Lee,Åsa B. Gustafsson,Robert M. Mentzer,Roberta A. Gottlieb +6 more
TL;DR: Results indicate that autophagy plays an important role in mediating the cardioprotective effects conferred by adenosine pretreatment, and is monitored by imaging the incorporation of microtubule-associated light chain 3 fused to a fluorescent protein (GFP or mCherry) into nascent autophagosomes.
Journal ArticleDOI
Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production.
TL;DR: Data indicate that calcineurin signaling affects mitochondrial energetics and superoxide production, and the excessive production of superoxide may contribute to the development of cardiac failure.
Journal ArticleDOI
Bnip3 as a Dual Regulator of Mitochondrial Turnover and Cell Death in the Myocardium
TL;DR: Current understanding of the functional role that Bnip3 plays in the myocardium is discussed, where it regulates both mitochondrial turnover via autophagy and cell death and that these are two separate processes activated by BnIP3.