S
Smadar Yitzhaki
Researcher at San Diego State University
Publications - 3
Citations - 350
Smadar Yitzhaki is an academic researcher from San Diego State University. The author has contributed to research in topics: Autophagy & Adenosine A1 receptor. The author has an hindex of 3, co-authored 3 publications receiving 341 citations.
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Journal ArticleDOI
Autophagy induced by ischemic preconditioning is essential for cardioprotection.
Chengqun Huang,Smadar Yitzhaki,Cynthia N. Perry,Cynthia N. Perry,Wayne Liu,Zoltán Giricz,Robert M. Mentzer,Robert M. Mentzer,Roberta A. Gottlieb +8 more
TL;DR: Findings establish autophagy as an end-effector in ischemic and pharmacologic preconditioning and assesses three structurally unrelated cardioprotective agents for their ability to induce Autophagy in HL-1 cells.
Journal ArticleDOI
Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA
Smadar Yitzhaki,Chengqun Huang,Wayne Liu,Youngil Lee,Åsa B. Gustafsson,Robert M. Mentzer,Roberta A. Gottlieb +6 more
TL;DR: Results indicate that autophagy plays an important role in mediating the cardioprotective effects conferred by adenosine pretreatment, and is monitored by imaging the incorporation of microtubule-associated light chain 3 fused to a fluorescent protein (GFP or mCherry) into nascent autophagosomes.
Journal ArticleDOI
Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole.
Chengqun Huang,Wayne Liu,Cynthia N. Perry,Smadar Yitzhaki,Youngil Lee,Hua Yuan,Yayoi Tetsuo Tsukada,Anne Hamacher-Brady,Robert M. Mentzer,Robert M. Mentzer,Roberta A. Gottlieb +10 more
TL;DR: These studies indicate that cardioprotection mediated by SUL involves a PKC-dependent induction of autophagy, and suggest that autophagic may be a fundamental process that enhances the heart's tolerance to ischemia.