A
Asad M. Taherbhoy
Researcher at St. Jude Children's Research Hospital
Publications - 7
Citations - 521
Asad M. Taherbhoy is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Autophagy & ATG8. The author has an hindex of 5, co-authored 7 publications receiving 468 citations. Previous affiliations of Asad M. Taherbhoy include University of Tennessee Health Science Center.
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Journal ArticleDOI
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.
Danny T. Huang,Olivier Ayrault,Harold W. Hunt,Asad M. Taherbhoy,Asad M. Taherbhoy,David M. Duda,Daniel C. Scott,Laura A. Borg,Geoffrey Neale,Peter J. Murray,Martine F. Roussel,Martine F. Roussel,Brenda A. Schulman +12 more
TL;DR: Together, these studies reveal the molecular basis for and functional importance of hierarchical expansion of the NEDD8 conjugation system in establishing selective CRL activation.
Journal ArticleDOI
Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.
Asad M. Taherbhoy,Stephen W.G. Tait,Stephen E. Kaiser,Allison H. Williams,Alan Deng,Amanda Nourse,Michal Hammel,Igor Kurinov,Charles O. Rock,Douglas R. Green,Brenda A. Schulman,Brenda A. Schulman +11 more
TL;DR: The structures and biochemical data provide a rationale for Atg7 dimerization and reveal a distinctive E1~UBL-E2 architecture for enzymes mediating autophagy.
Journal ArticleDOI
Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7–Atg3 and Atg7–Atg10 structures
Stephen E. Kaiser,Kai Mao,Asad M. Taherbhoy,Asad M. Taherbhoy,Shanshan Yu,Shanshan Yu,Jennifer L. Olszewski,David M. Duda,Igor Kurinov,Alan Deng,Timothy D. Fenn,Daniel J. Klionsky,Brenda A. Schulman +12 more
TL;DR: The data suggest that common principles underlie conjugation in both noncanonical and canonical UBL cascades, whereby flexibly tethered E1 domains recruit E2s through surfaces remote from their active sites to juxtapose the E1 and E2 catalytic cysteines.
Journal ArticleDOI
Crystal Structure of UBA2ufd-Ubc9: Insights into E1-E2 Interactions in Sumo Pathways
Jing Wang,Asad M. Taherbhoy,Asad M. Taherbhoy,Harold W. Hunt,Steven N. Seyedin,David W Miller,Darcie J. Miller,Danny T. Huang,Brenda A. Schulman,Brenda A. Schulman +9 more
TL;DR: In this paper, the C-terminal ubiquitin fold domain (ufd) from yeast Uba2 (Uba2(ufd)), alone and in complex with Ubc9, was determined.
Journal ArticleDOI
Ubiquitin-like modifiers.
TL;DR: This chapter highlights a subset of UBLs (ubiquitin-like proteins) and describes their regulatory roles in the cell.