A
Asao Hirano
Researcher at Yeshiva University
Publications - 5
Citations - 1476
Asao Hirano is an academic researcher from Yeshiva University. The author has contributed to research in topics: Fluid compartments & Parkinsonism. The author has an hindex of 5, co-authored 5 publications receiving 1335 citations. Previous affiliations of Asao Hirano include Kansai Medical University.
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Journal ArticleDOI
Mutations of optineurin in amyotrophic lateral sclerosis
Hirofumi Maruyama,Hiroyuki Morino,Hidefumi Ito,Hidefumi Ito,Yuishin Izumi,Hidemasa Kato,Yasuhito Watanabe,Yoshimi Kinoshita,Masaki Kamada,Masaki Kamada,Hiroyuki Nodera,Hidenori Suzuki,Osamu Komure,Shinya Matsuura,Keitaro Kobatake,Nobutoshi Morimoto,Koji Abe,Naoki Suzuki,Masashi Aoki,Akihiro Kawata,Takeshi Hirai,Takeo Kato,Kazumasa Ogasawara,Asao Hirano,Toru Takumi,Hirofumi Kusaka,Koichi Hagiwara,Ryuji Kaji,Hideshi Kawakami +28 more
TL;DR: It is shown that there are mutations in the gene encoding optineurin (OPTN), earlier reported to be a causative gene of primary open-angle glaucoma (POAG), in patients with ALS and these findings strongly suggest that OPTN is involved in the pathogenesis of ALS.
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Functional anatomy of the basal ganglia in X-linked recessive dystonia-parkinsonism
Satoshi Goto,Lillian V. Lee,Edwin L. Munoz,Ikuo Tooyama,Gen Tamiya,Satoshi Makino,Satoshi Ando,Marita B. Dantes,Kazumichi Yamada,Sadayuki Matsumoto,Hideki Shimazu,Jun Ichi Kuratsu,Asao Hirano,Ryuji Kaji +13 more
TL;DR: This study is the first to the authors' knowledge to show specific basal ganglia pathology that could explain the genesis of dystonia in human heredodegenerative movement disorders, suggesting that dySTONia may result from an imbalance in the activity between the striosomal and matrix‐based pathways.
Journal ArticleDOI
Nuclear contour irregularity and abnormal transporter protein distribution in anterior horn cells in amyotrophic lateral sclerosis.
Yoshimi Kinoshita,Hidefumi Ito,Asao Hirano,Kengo Fujita,Reika Wate,Masataka Nakamura,Satoshi Kaneko,Satoshi Nakano,Hirofumi Kusaka +8 more
TL;DR: Observations suggest that dysfunctional nucleocytoplasmic transport may underlie the pathogenesis of ALS.
Journal ArticleDOI
Clinicopathologic investigation of a family with expanded SCA8 CTA/CTG repeats
Hisashi Ito,Hideshi Kawakami,Hideshi Kawakami,Reika Wate,Sadayuki Matsumoto,T. Imai,Asao Hirano,H. Kusaka,H. Kusaka +8 more
TL;DR: This family manifesting progressive ataxia, with expanded SCA8 CTA/CTG repeats, with characteristic distribution of neurodegeneration and Purkinje cell cytopathology were distinct from those of other hereditary spinocerebellar ataxias previously reported.