Ashleigh B. Theberge

TL;DR: Examples are presented to show how compartmentalization, monodispersity, single-molecule sensitivity, and high throughput have been exploited in experiments that would have been extremely difficult outside the microfluidics platform.

TL;DR: Water-in-oil microdroplets in microfluidics are well-defined individual picoliter reaction compartments and, as such, have great potential for quantitative high-throughput biological screening, but leaking into the oil phase is shown to be dependent on the nature of the compounds and on the concentration of the silicone-based polymeric surfactant Abil EM 90 used.

TL;DR: An open microfluidic platform that uses surface tension to fill and maintain a fluid in microscale structures devoid of a ceiling and floor is presented and a simple and ubiquitous model predicting fluid flow in suspendedMicrofluidics is developed and it encompasses many known capillary phenomena.

TL;DR: This paper presents an efficient strategy for producing a 7 × 3 library of potential thrombin inhibitors that can be utilized for other combinatorial synthesis applications and holds great potential for other applications that involve sampling large areas of chemical parameter space with minimal reagent consumption.

TL;DR: A class of microscale culture platforms to analyse chemical diversity of fungal and bacterial secondary metabolomes by leveraging stable biphasic interfaces to integrate microculture with small molecule isolation via liquid–liquid extraction and enabling metabolomics-scale analysis using mass spectrometry is introduced.