C
Chun-Jun Guo
Researcher at Cornell University
Publications - 40
Citations - 2181
Chun-Jun Guo is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Microbiome. The author has an hindex of 17, co-authored 30 publications receiving 1252 citations. Previous affiliations of Chun-Jun Guo include Fudan University & NewYork–Presbyterian Hospital.
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Journal ArticleDOI
Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells
Clarissa Campbell,Peter T. McKenney,Peter T. McKenney,Daniel Konstantinovsky,Olga I Isaeva,Michail Schizas,Jacob Verter,Cheryl Mai,Wen-Bing Jin,Chun-Jun Guo,Sara Violante,Ruben J. Ramos,Justin R. Cross,Krishna Kadaveru,John Hambor,Alexander Y. Rudensky +15 more
TL;DR: It is found that the secondary bile acid 3β-hydroxydeoxycholic acid (isoDCA) increased Foxp3 induction by acting on dendritic cells (DCs) to diminish their immunostimulatory properties, suggesting an interaction between this bile Acid and nuclear receptor.
Journal ArticleDOI
Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids, austinol and dehydroaustinol in Aspergillus nidulans
Hsien-Chun Lo,Ruth Entwistle,Chun-Jun Guo,Manmeet Ahuja,Edyta Szewczyk,Jui-Hsiang Hung,Yi-Ming Chiang,Berl R. Oakley,Clay C. C. Wang +8 more
TL;DR: Chemical analysis of mutant extracts enabled us to isolate 3,5-dimethylorsellinic acid and 10 additional meroterpenoids that are either intermediates or shunt products from the biosynthetic pathway, and allow us to propose a complete biosynthesis pathway for the A. nidulans meroter penoids.
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A metabolic pathway for bile acid dehydroxylation by the gut microbiome
Masanori Funabashi,Masanori Funabashi,Tyler L. Grove,Min Wang,Yug Varma,Molly E. McFadden,Laura C. Brown,Chun-Jun Guo,Steven K. Higginbottom,Steven C. Almo,Michael A. Fischbach +10 more
TL;DR: The biosynthetic pathway that produces the secondary bile acids DCA and LCA in human gut microbes has been fully characterized, engineered into another bacterial host, and used to confer DCA production in germ-free mice—an important proof-of-principle for the engineering of gut microbial pathways.
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Prototype of an intertwined secondary-metabolite supercluster
Philipp Wiemann,Chun-Jun Guo,Jonathan M. Palmer,Relebohile Sekonyela,Clay C. C. Wang,Nancy P. Keller +5 more
TL;DR: Comparative genomics indicates the fumagillin/pseurotin supercluster is maintained in a rapidly evolving region of diverse fungal genomes, which confounds predictions from established secondary-metabolite cluster search algorithms and provides an expanded view of natural product evolution.
Journal ArticleDOI
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases.
Chun-Jun Guo,Fang-Yuan Chang,Thomas P. Wyche,Keriann M. Backus,Timothy M. Acker,Funabashi Masanori,Mao Taketani,Mohamed S. Donia,Stephen Nayfach,Katherine S. Pollard,Charles S. Craik,Benjamin F. Cravatt,Jon Clardy,Christopher A. Voigt,Michael A. Fischbach +14 more
TL;DR: The findings show that an approach combining bioinformatics, synthetic biology, and heterologous gene cluster expression can rapidly expand the knowledge of the metabolic potential of the microbiota while avoiding the challenges of cultivating fastidious commensals.