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Ashley N. Hutchinson
Researcher at Duke University
Publications - 10
Citations - 648
Ashley N. Hutchinson is an academic researcher from Duke University. The author has contributed to research in topics: Placebo & Medicine. The author has an hindex of 5, co-authored 5 publications receiving 572 citations.
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Journal ArticleDOI
Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function
Sonia Cohen,Harrison W. Gabel,Martin Hemberg,Ashley N. Hutchinson,L. Amanda Sadacca,Daniel H. Ebert,David A. Harmin,Rachel S. Greenberg,Vanessa K. Verdine,Zhaolan Zhou,William C. Wetsel,Anne E. West,Michael E. Greenberg +12 more
TL;DR: It is shown here that disruption of MeCP2 S421 phosphorylation in vivo results in defects in synapse development and behavior, implicating activity-dependent regulation of Me CP2 in brain development and RTT.
Journal ArticleDOI
MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants
Jie V. Deng,Ramona M. Rodriguiz,Ashley N. Hutchinson,Il Hwan Kim,William C. Wetsel,Anne E. West +5 more
TL;DR: It is shown that acute viral manipulation of MeCP2 expression in the nucleus accumbens (NAc) bidirectionally modulates amphetamine (AMPH)-induced conditioned place preference and reveals new roles for Me CP2 both in mesolimbocortical circuit development and in the regulation of psychostimulant-induced behaviors.
Journal ArticleDOI
Reduced Cortical BDNF Expression and Aberrant Memory in Carf Knock-Out Mice
Kelli A. McDowell,Ashley N. Hutchinson,Sarah J.E. Wong-Goodrich,Matthew M. Presby,Dan Su,Ramona M. Rodriguiz,Krystal C. Law,Christina L. Williams,William C. Wetsel,Anne E. West +9 more
TL;DR: Novel roles for CaRF in the organization and/or function of neural circuits that underlie essential aspects of learning and memory are revealed.
Journal ArticleDOI
Phosphorylation of MeCP2 at Ser421 contributes to chronic antidepressant action.
TL;DR: It is shown that methyl-CpG-binding protein 2 (MeCP2) regulates behavioral responses to chronic antidepressant treatment and that pMe CP2 is required for the effects of chronic imipramine on depressive-like behaviors induced by chronic social defeat stress.
Journal ArticleDOI
Differential Regulation of MeCP2 Phosphorylation in the CNS by Dopamine and Serotonin
TL;DR: Combinatorial signaling through DA and 5-HT receptors can regulate the brain region- and cell-type specific pMeCP2 in the CNS, suggesting that the combinatorial regulation of cAMP by different classes of DA and5- HT receptors may contribute to the cell- type specificity of pMe CP2 induction.