H
Harrison W. Gabel
Researcher at Washington University in St. Louis
Publications - 44
Citations - 5171
Harrison W. Gabel is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Gene & DNA methylation. The author has an hindex of 17, co-authored 37 publications receiving 4553 citations. Previous affiliations of Harrison W. Gabel include Harvard University.
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Journal ArticleDOI
A Map of the Interactome Network of the Metazoan C. elegans
Siming Li,Christopher M. Armstrong,Nicolas Bertin,Hui Ge,Stuart Milstein,Mike Boxem,Pierre-Olivier Vidalain,Jing-Dong J. Han,Alban Chesneau,Tong Hao,Debra S. Goldberg,Ning Li,Monica Martinez,Jean François Rual,Philippe Lamesch,Lai Xu,Lai Xu,Muneesh Tewari,Sharyl L. Wong,Lan V. Zhang,Gabriel F. Berriz,Laurent Jacotot,Philippe Vaglio,Jérôme Reboul,Tomoko Hirozane-Kishikawa,Qian-Ru Li,Harrison W. Gabel,Ahmed Elewa,Ahmed Elewa,Bridget L. Baumgartner,Debra J. Rose,Haiyuan Yu,Stephanie Bosak,Reynaldo Sequerra,Andrew G. Fraser,Susan E. Mango,William M. Saxton,Susan Strome,Sander van den Heuvel,Fabio Piano,Jean Vandenhaute,Claude Sardet,Mark Gerstein,Lynn Doucette-Stamm,Kristin C. Gunsalus,J. Wade Harper,J. Wade Harper,Michael E. Cusick,Frederick P. Roth,David E. Hill,Marc Vidal +50 more
TL;DR: A large fraction of the Caenorhabditis elegans interactome network is mapped, starting with a subset of metazoan-specific proteins, and more than 4000 interactions were identified from high-throughput, yeast two-hybrid screens.
Journal ArticleDOI
Disruption of DNA methylation-dependent long gene repression in Rett syndrome
Harrison W. Gabel,Benyam Kinde,Hume Stroud,Caitlin S. Gilbert,David A. Harmin,Nathaniel R. Kastan,Martin Hemberg,Daniel H. Ebert,Michael E. Greenberg +8 more
TL;DR: A genome-wide length-dependent increase in gene expression is identified in MeCP2 mutant mouse models and human RTT brains, and it is found that long genes as a population are enriched for neuronal functions and selectively expressed in the brain.
Journal ArticleDOI
Npas4 Regulates Excitatory-Inhibitory Balance within Neural Circuits through Cell-Type-Specific Gene Programs
Ivo Spiegel,Alan R. Mardinly,Harrison W. Gabel,Jeremy E. Bazinet,Cameron H. Couch,Christopher P. Tzeng,David A. Harmin,Michael E. Greenberg +7 more
TL;DR: These findings suggest that the functional outcomes of activity-induced transcriptional responses are adapted in a cell-type-specific manner to achieve a circuit-wide homeostatic response.
Journal ArticleDOI
Functional genomic analysis of RNA interference in C. elegans
John Kim,Harrison W. Gabel,Ravi S. Kamath,Muneesh Tewari,Amy E. Pasquinelli,Jean François Rual,Scott Kennedy,Michael Dybbs,Nicolas Bertin,Joshua M. Kaplan,Marc Vidal,Gary Ruvkun +11 more
TL;DR: It is demonstrated that some of these genes are also required for germline and somatic transgene silencing, and the physical interactions among these potential RNAi factors suggest links to other RNA-dependent gene regulatory pathways.
Journal ArticleDOI
Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function
Sonia Cohen,Harrison W. Gabel,Martin Hemberg,Ashley N. Hutchinson,L. Amanda Sadacca,Daniel H. Ebert,David A. Harmin,Rachel S. Greenberg,Vanessa K. Verdine,Zhaolan Zhou,William C. Wetsel,Anne E. West,Michael E. Greenberg +12 more
TL;DR: It is shown here that disruption of MeCP2 S421 phosphorylation in vivo results in defects in synapse development and behavior, implicating activity-dependent regulation of Me CP2 in brain development and RTT.