A
Ashutosh Shandilya
Researcher at Indian Institute of Technology Delhi
Publications - 26
Citations - 868
Ashutosh Shandilya is an academic researcher from Indian Institute of Technology Delhi. The author has contributed to research in topics: Docking (molecular) & CDC37. The author has an hindex of 15, co-authored 24 publications receiving 754 citations. Previous affiliations of Ashutosh Shandilya include Indian Institutes of Technology.
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Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera’s key metabolite withaferin A
TL;DR: This study attempts to explore NF-κB signalling pathway modulating capability of Withania somnifera’s major constituent WA and to elucidate its possible mode of action using molecular docking and molecular dynamics simulations studies.
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A plausible mechanism for the antimalarial activity of artemisinin: A computational approach
TL;DR: Results suggest that artemisinin gets activated by iron which in turn inhibits PfATP6 by closing the phosphorylation, nucleotide binding and actuator domains leading to loss of function of PfATp6 of the parasite and its death.
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Hsp90/Cdc37 Chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A
Abhinav Grover,Ashutosh Shandilya,Vibhuti Agrawal,Piyush Pratik,Divya Bhasme,Virendra S. Bisaria,Durai Sundar +6 more
TL;DR: The study conducted here is an attempt to explore the potential of Withania somnifera’s major constituent WA (Withaferin A) in attenuating the Hsp90/Cdc37 chaperone/co-chaperone interactions for enhanced tumor arresting activity and to elucidate the underlying mode of action using computational approaches.
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Curcumin specifically binds to the human calcium–calmodulin-dependent protein kinase IV: fluorescence and molecular dynamics simulation studies
Nasimul Hoda,Huma Naz,Ehtesham Jameel,Ashutosh Shandilya,Sharmistha Dey,Md. Imtaiyaz Hassan,Faizan Ahmad,Bhyravabhotla Jayaram +7 more
TL;DR: In insights into designing a new inspired curcumin derivatives as therapeutic agents against many life-threatening diseases, the interaction ofCurcumin with human CAMK4 is studied using molecular docking, molecular dynamics simulations, fluorescence binding, and surface plasmon resonance (SPR) methods.
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Withanone binds to mortalin and abrogates mortalin-p53 complex: computational and experimental evidence.
Abhinav Grover,Didik Priyandoko,Ran Gao,Ashutosh Shandilya,Nashi Widodo,Virendra S. Bisaria,Sunil C. Kaul,Renu Wadhwa,Durai Sundar +8 more
TL;DR: A molecular interaction basis that could be used for screening and development of anticancer drugs with low toxicity to normal cells is established and accurate knowledge of the 3D structure of mortalin would further enhance the potential of such analyses to understand the molecular basis ofmortalin biology and mortalin based cancer therapy.