A
Ashutosh Shandilya
Researcher at Indian Institute of Technology Delhi
Publications - 26
Citations - 868
Ashutosh Shandilya is an academic researcher from Indian Institute of Technology Delhi. The author has contributed to research in topics: Docking (molecular) & CDC37. The author has an hindex of 15, co-authored 24 publications receiving 754 citations. Previous affiliations of Ashutosh Shandilya include Indian Institutes of Technology.
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Development of cyanopyridine-triazine hybrids as lead multitarget anti-Alzheimer agents.
Mudasir Maqbool,Apra Manral,Ehtesham Jameel,Jitendra Kumar,Vikas Saini,Ashutosh Shandilya,Manisha Tiwari,Nasimul Hoda,Bhyravabhotla Jayaram +8 more
TL;DR: Results from neuroprotection studies of most potent compounds 4d and 4h indicate that these derivatives can reduce neuronal death induced by H2O2-mediated oxidative stress and Aβ1-42 induced cytotoxicity.
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Structure guided design of potential inhibitors of human calcium-calmodulin dependent protein kinase IV containing pyrimidine scaffold.
Huma Naz,Ehtesham Jameel,Nasimul Hoda,Ashutosh Shandilya,Parvez Khan,Asimul Islam,Faizan Ahmad,Bhyravabhotla Jayaram,Md. Imtaiyaz Hassan +8 more
TL;DR: Some important observations are revealed to generate an improved pyrimidine based compound that holds promise as a therapeutic agent for the treatment of cancer and neurodegenerative diseases.
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Bispidine as a secondary structure nucleator in peptides
TL;DR: Bispidine is described as a scaffold for inducing open turn-like and beta sheet conformations on the attached peptides depending on the mode of attachment of peptides to the scaffold.
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Pyrimidine-Triazolopyrimidine and Pyrimidine-Pyridine Hybrids as Potential Acetylcholinesterase Inhibitors for Alzheimer's Disease
Jitendra Kumar,Asim Gill,Marziya Shaikh,Anju Singh,Ashutosh Shandilya,Ehtesham Jameel,Nitin Sharma,Nirotpal Mrinal,Nasimul Hoda,Bhyravabhotla Jayaram +9 more
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Effect of pH on the stability of hemochromatosis factor E: a combined spectroscopic and molecular dynamics simulation-based study.
Parvez Khan,Ashutosh Shandilya,Bhyravabhotla Jayaram,Asimul Islam,Faizan Ahmad,Md. Imtaiyaz Hassan +5 more
TL;DR: It is postulated that, might be low pH of cancerous cells helps them to meet their high iron requirement, and the contribution of salt bridges to the stability of HFE is analyzed.