A
Asier González
Researcher at University of Basel
Publications - 11
Citations - 1159
Asier González is an academic researcher from University of Basel. The author has contributed to research in topics: Saccharomyces cerevisiae & Protein kinase A. The author has an hindex of 8, co-authored 11 publications receiving 745 citations.
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Journal ArticleDOI
Nutrient sensing and TOR signaling in yeast and mammals
Asier González,Michael N. Hall +1 more
TL;DR: How nutrient availability is sensed and transduced to TOR in budding yeast and mammals is reviewed to allow novel strategies in the treatment for mTOR‐related diseases.
Journal ArticleDOI
AMPK and TOR: the Yin and Yang of cellular nutrient sensing and growth control
TL;DR: The evolution, structure, and regulation of the AMPK and TOR pathways and the complex mechanisms by which they interact are discussed.
Journal ArticleDOI
The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control
TL;DR: The fundamentally important roles of these two kinases in the regulation of cell growth are reviewed with particular emphasis on their mutually antagonistic signaling.
Journal ArticleDOI
TORC1 Promotes Phosphorylation of Ribosomal Protein S6 via the AGC Kinase Ypk3 in Saccharomyces cerevisiae
Asier González,Mitsugu Shimobayashi,Tobias Eisenberg,David A. Merle,Tobias Pendl,Michael N. Hall,Tarek Moustafa +6 more
TL;DR: It is found that nutrients rapidly induce Rps6 phosphorylation in a TORC1-dependent manner and that the use of a phospho-S6 specific antibody offers a valuable tool to identify new nutrient-dependent and rapamycin-sensitive targets in vivo.
Journal ArticleDOI
Inferring causal metabolic signals that regulate the dynamic TORC1-dependent transcriptome
Ana Paula Oliveira,Sotiris Dimopoulos,Alberto Giovanni Busetto,Stefan Christen,Reinhard Dechant,Laura Falter,Morteza Haghir Chehreghani,Szymon Jozefczuk,Christina Ludwig,Florian Rudroff,Juliane Caroline Schulz,Asier González,Alexandre Soulard,Alexandre Soulard,Daniele Stracka,Ruedi Aebersold,Ruedi Aebersold,Joachim M. Buhmann,Michael N. Hall,Matthias Peter,Uwe Sauer,Jörg Stelling +21 more
TL;DR: This work analyzed the dynamic regulation of nitrogen metabolism by the target of rapamycin complex 1 (TORC1) pathway in budding yeast and co‐designed dynamic experiments and a probabilistic, model‐based method to infer causal relationships between metabolism, signaling, and gene regulation.