Tarek Moustafa

TL;DR: It is shown that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice, and suggests a new and feasible strategy for protection against cardiovascular disease.

TL;DR: HULC is the first ncRNA with highly specific up-regulation in HCC, suggesting a role for HULC in post-transcriptional modulation of gene expression.

TL;DR: Reconstituting normal PPAR target gene expression by pharmacological treatment of Atgl-deficient mice with PPAR-α agonists completely reverses the mitochondrial defects, restores normal heart function and prevents premature death.

TL;DR: It is demonstrated that DDC feeding in mice leads to a reactive phenotype of cholangiocytes and bile duct injury, pericholangitis, periductal fibrosis, ductular reaction, and consequently portal-portal bridging, and down-regulation of Mrp2 and impaired glutathione excretion, which may be valuable to investigate the mechanisms of xenobiotic-induced chronicCholangiopathies and its sequels including biliary fibrosis.

TL;DR: Findings suggest that BA and targeting their receptor/signaling pathways may represent a promising approach to treat NAFLD and closely linked disorders such as obesity, diabetes, dyslipidemia and arteriosclerosis.