Asli Muvaffak

TL;DR: This work conducts humanization and affinity optimization of a murine anti-CCR4 monoclonal antibody that recognizes both the N-terminal and extracellular domains of CCR4 with high affinity and inhibits chemotaxis of C CR4+ CTCL cells.

TL;DR: The results suggested the potential application of gelatin microspheres crosslinked with GTA as a sustained drug-delivery system for anticancer drugs for local chemotherapy administrations.

TL;DR: The data demonstrate that the in vivo anti-tumor activity of h1567 minibody is mediated, at least in part, through CD16A+ immune effector cell ADCC mechanisms, and further demonstrate the utility of the AAV-minibody gene transfer system in the rapid evaluation of candidate anti-Tumor mAbs and the potency of h 1567 as a potential novel therapy for CTCL.

TL;DR: Based on their low cytotoxicity and the high antigen binding efficiencies, anti-BSA conjugated gelatin microspheres could be suitable targeted drug carrier systems for selective and long-term delivery of anticancer drugs to a specific body compartment.

TL;DR: The influence of preparation compositions on microsphere recovery, particle size and morphology, swelling and degradation, 5-fluorouracil loading and release, and cytotoxicity were investigated.