R
Robert C. Fuhlbrigge
Researcher at University of Colorado Denver
Publications - 113
Citations - 12510
Robert C. Fuhlbrigge is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: T cell & Population. The author has an hindex of 49, co-authored 106 publications receiving 11529 citations. Previous affiliations of Robert C. Fuhlbrigge include Harvard University & Brigham and Women's Hospital.
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Journal ArticleDOI
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
Conrad C. Bleul,Robert C. Fuhlbrigge,José M. Casasnovas,Alessandro Aiuti,Timothy A. Springer +4 more
TL;DR: A highly efficacious lymphocytes chemotactic activity in the supernatants of the murine bone marrow stroma cell line MS-5 is identified which attracts 10-fold more lymphocytes in vitro than currently described lymphocyte chemoattractants.
Journal ArticleDOI
Identification of cells initiating human melanomas
Tobias Schatton,George F. Murphy,Natasha Y. Frank,Kazuhiro Yamaura,Ana Maria Waaga-Gasser,Martin Gasser,Qian Zhan,Stefan Jordan,Lyn M. Duncan,Carsten Weishaupt,Robert C. Fuhlbrigge,Thomas S. Kupper,Mohamed H. Sayegh,Markus H. Frank +13 more
TL;DR: This work identifies a subpopulation enriched for human malignant-melanoma-initiating cells (MMIC) defined by expression of the chemoresistance mediator ABCB5 and shows that specific targeting of this tumorigenic minority population inhibits tumour growth.
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Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition
Raphaela Goldbach-Mansky,Natalie J Dailey,Scott W. Canna,Ana Gelabert,Janet Jones,Benjamin I. Rubin,H. Jeffrey Kim,Carmen C. Brewer,Christopher K. Zalewski,Edythe Wiggs,Suvimol Hill,Maria L. Turner,Barbara I. Karp,Ivona Aksentijevich,Frank Pucino,Scott R. Penzak,Margje H. Haverkamp,Leonard D. Stein,Barbara S. Adams,Terry L. Moore,Robert C. Fuhlbrigge,Bracha Shaham,James N. Jarvis,Kathleen M. O'Neil,Richard K. Vehe,Laurie O Beitz,Gregory C. Gardner,William P Hannan,Robert W. Warren,William Horn,Joe L Cole,Scott M. Paul,Philip N. Hawkins,T. Pham,Christopher Snyder,Robert Wesley,Steven C. Hoffmann,Steven M. Holland,John A. Butman,Daniel L. Kastner +39 more
TL;DR: Daily injections of anakinra markedly improved clinical and laboratory manifestations in patients with neonatal-onset multisystem inflammatory disease, with or without CIAS1 mutations.
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Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity.
Xiaodong Jiang,Rachael A. Clark,Luzheng Liu,Amy J. Wagers,Robert C. Fuhlbrigge,Thomas S. Kupper +5 more
TL;DR: It is shown in mice that localized vaccinia virus (VACV) skin infection generates long-lived non-recirculating CD8+ skin TRM cells that reside within the entire skin that are superior to circulating central memory T (TCM) cells at providing rapid long-term protection against cutaneous re-infection.
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Immune surveillance in the skin: mechanisms and clinical consequences
TL;DR: The interaction between the innate and adaptive immune systems in the skin as a model for immune function at epithelial-cell interfaces with the environment is discussed.