A
Atefeh Rabiee
Researcher at Stanford University
Publications - 25
Citations - 609
Atefeh Rabiee is an academic researcher from Stanford University. The author has contributed to research in topics: Adipogenesis & Cellular differentiation. The author has an hindex of 7, co-authored 22 publications receiving 406 citations. Previous affiliations of Atefeh Rabiee include University of the Pacific (United States) & Islamic Azad University.
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Journal ArticleDOI
Transcription Factor Cooperativity in Early Adipogenic Hotspots and Super-Enhancers
Rasmus Siersbæk,Atefeh Rabiee,Ronni Nielsen,Simone Sidoli,Sofie Traynor,Anne Loft,Lars la Cour Poulsen,Adelina Rogowska-Wrzesinska,Ole N. Jensen,Susanne Mandrup +9 more
TL;DR: It is demonstrated that hotspots are highly enriched in large super-enhancer regions (several kilobases), which drive the early adipogenic reprogramming of gene expression, and cooperativity between transcription factors at the level of hotspots as well assuper-enhancers is very important for enhancer activity and transcriptional reprograming.
Journal ArticleDOI
Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility.
Ryan S. Stowers,Anna Shcherbina,Johnny Israeli,Joshua J. Gruber,Julie Chang,Sungmin Nam,Atefeh Rabiee,Mary N. Teruel,Michael Snyder,Anshul Kundaje,Ovijit Chaudhuri +10 more
TL;DR: 3D model of breast cancer shows that a stiff extracellular matrix promotes a tumorigenic phenotype through broad changes in chromatin accessibility and in the activity of histone deacetylases and the transcription factor Sp1, and reveals that chromatin state is a critical mediator of mechanotransduction.
Journal ArticleDOI
Molecular architecture of transcription factor hotspots in early adipogenesis.
Rasmus Siersbæk,Songjoon Baek,Atefeh Rabiee,Ronni Nielsen,Sofie Traynor,Nicholas Clark,Albin Sandelin,Ole N. Jensen,Myong-Hee Sung,Gordon L. Hager,Susanne Mandrup +10 more
TL;DR: Digital genomic footprinting is used to precisely define factor localization at a genome-wide level during the early phase of 3T3-L1 adipocyte differentiation, which allows for detailed molecular insight into how transcription factors target hotspots and provides a framework for understanding transcription factor cooperativity in hotspots.
Journal ArticleDOI
Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action.
TL;DR: By generating a comprehensive phosphoproteomic profile from brown preadipocyte cells in response to IGF-1 stimulation, this work reveals both common and distinct insulin/IGF-1 signalling events mediated by specific IRS proteins.
Journal ArticleDOI
How curcumin affords effective protection against amyloid fibrillation in insulin
Atefeh Rabiee,Azadeh Ebrahim-Habibi,Atiyeh Ghasemi,Mohsen Nemat-Gorgani,Mohsen Nemat-Gorgani +4 more
TL;DR: In this study, insulin amyloid formation has been shown to be effectively influenced by micromolar concentrations of curcumin, and this compound appears to be able to interact with native, intermediate and fibrillar forms.