Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action.
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TLDR
By generating a comprehensive phosphoproteomic profile from brown preadipocyte cells in response to IGF-1 stimulation, this work reveals both common and distinct insulin/IGF-1 signalling events mediated by specific IRS proteins.About:
This article is published in Cellular Signalling.The article was published on 2018-03-14 and is currently open access. It has received 37 citations till now. The article focuses on the topics: Insulin receptor substrate & Protein kinase C.read more
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PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin.
Aurèle Besse-Patin,Stewart Jeromson,Stewart Jeromson,Philipa Levesque-Damphousse,Blandine Secco,Mathieu Laplante,Jennifer L. Estall +6 more
TL;DR: PGC1A controls the hepatic ratio of Insulin Receptor Substrates 1 (IRS1) and IRS2 expression, crucial for defining the precise insulin signal in hepatocytes to respond to fasting and feeding, and is key for insulin-mediated suppression of hepatic glucose production.
Journal ArticleDOI
Defining the underlying defect in insulin action in type 2 diabetes
TL;DR: In this article, the authors used human induced pluripotent stem cells and tissues point to cell-autonomous alterations in signalling super-networks, involving changes in phosphorylation and gene expression both inside and outside the canonical insulin signalling pathway.
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Disorders of IGFs and IGF-1R signaling pathways.
TL;DR: This review provides a brief introduction to the IGF system and summarizes findings from reports arising from recent larger genomic sequencing studies of human genetic mutations in IGF1 and IGF2 and genes of proteins regulating IGF action, namely the IGF1R, IGF-1R signaling pathway components and the IGF binding proteins (IGFBPs).
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Insulin Signal Transduction Perturbations in Insulin Resistance.
TL;DR: In this article, the defects in the insulin signal transduction pathway of the insulin resistance state with special emphasis on the AGE-RAGE-NF-κB axis are discussed.
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Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains.
Hirofumi Nagao,Weikang Cai,Weikang Cai,Nicolai J. Wewer Albrechtsen,Nicolai J. Wewer Albrechtsen,Martin Steger,Thiago M. Batista,Hui Pan,Jonathan M. Dreyfuss,Matthias Mann,Matthias Mann,C. Ronald Kahn +11 more
TL;DR: There are important differences in phosphorylation-mediated signaling between IR and IGF1R in both the basal and ligand-stimulated states involving multiple pathways of cellular regulation, allowing for the unique effects of these hormones on organismal function.
References
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TL;DR: SILAC is a simple, inexpensive, and accurate procedure that can be used as a quantitative proteomic approach in any cell culture system and is applied to the relative quantitation of changes in protein expression during the process of muscle cell differentiation.
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REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms
TL;DR: REVIGO is a Web server that summarizes long, unintelligible lists of GO terms by finding a representative subset of the terms using a simple clustering algorithm that relies on semantic similarity measures.
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GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists
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TL;DR: GOrilla is a web-based application that identifies enriched GO terms in ranked lists of genes, without requiring the user to provide explicit target and background sets, and its unique features and advantages over other threshold free enrichment tools include rigorous statistics, fast running time and an effective graphical representation.
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Critical nodes in signalling pathways: Insights into insulin action
TL;DR: The concept of 'critical nodes' is used to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.