A
Athena P. Y. Li
Researcher at University of Hong Kong
Publications - 9
Citations - 258
Athena P. Y. Li is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Vaccination & Influenza vaccine. The author has an hindex of 5, co-authored 9 publications receiving 99 citations. Previous affiliations of Athena P. Y. Li include Li Ka Shing Faculty of Medicine, University of Hong Kong.
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Journal ArticleDOI
SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection.
Carolyn A Cohen,Athena P. Y. Li,Asmaa Hachim,David Sc Hui,Mike Y W Kwan,Owen Tak-Yin Tsang,Susan S. Chiu,Wai Hung Chan,Yat Sun Yau,Niloufar Kavian,Fionn N L Ma,Eric H. Y. Lau,Samuel M.S. Cheng,Leo L.M. Poon,J. S. Malik Peiris,Sophie A. Valkenburg +15 more
TL;DR: In this paper, the authors report SARS-CoV-2 specific T cell responses in infected adults and children and find that the acute and memory CD4+ and CD8+ responses to structural SARS CoV2 proteins increase with age, whereas CD 8+ T cells responses increase with time post-infection.
Journal ArticleDOI
Comparative Immunogenicity of Several Enhanced Influenza Vaccine Options for Older Adults: A Randomized, Controlled Trial
Benjamin J. Cowling,Ranawaka A.P.M. Perera,Sophie A. Valkenburg,Nancy H. L. Leung,A. Danielle Iuliano,YH Tam,Jennifer H. F. Wong,Vicky J. Fang,Athena P. Y. Li,Hau Chi So,Dennis K. M. Ip,Eduardo Azziz-Baumgartner,Alicia M. Fry,Min Z. Levine,Shivaprakash Gangappa,Suryaprakash Sambhara,Ian G Barr,Ian G Barr,Danuta M. Skowronski,J. S. Malik Peiris,Mark G. Thompson +20 more
TL;DR: In this head-to-head comparison, older adults receiving enhanced vaccines showed improved humoral and cell-mediated immune responses, compared to standard-dose vaccine recipients.
Posted ContentDOI
SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection
Carolyn A Cohen,Athena P. Y. Li,Asmaa Hachim,David Sc Hui,Mike Y W Kwan,Owen Tak-Yin Tsang,Susan S. Chiu,Wai Hung Chan,Yat Sun Yau,Niloufar Kavian,Fionn N L Ma,Eric H. Y. Lau,Samuel M.S. Cheng,Leo L.M. Poon,J. S. Malik Peiris,Sophie A. Valkenburg +15 more
TL;DR: Reduced prior b-coronavirus immunity and reduced activation and recruitment of de novo responses in children may drive milder COVID-19 pathogenesis.
Journal ArticleDOI
The Hurdles From Bench to Bedside in the Realization and Implementation of a Universal Influenza Vaccine
Sophie A. Valkenburg,Nancy H. L. Leung,Maireid B. Bull,Li-Meng Yan,Athena P. Y. Li,Leo L.M. Poon,Benjamin J. Cowling +6 more
TL;DR: Improvements in vaccine design are needed to increase the strength, breadth, and duration of immunity against diverse strains that circulate during regular epidemics, occasional pandemics, and from animal reservoirs.
Journal ArticleDOI
Protection by universal influenza vaccine is mediated by memory CD4 T cells.
Sophie A. Valkenburg,Olive T. W. Li,Athena P. Y. Li,Maireid B. Bull,Thomas A. Waldmann,Liyanage P. Perera,Malik Peiris,Leo L.M. Poon +7 more
TL;DR: A novel universal vaccine is developed which elicits robust T cell responses and protection against diverse influenza viruses in mouse and human models and boosted H5-specific T cells from human PBMCs, specifically CD4+ and CD8+ T effector memory type, ensuring the vaccine was truly universal for its future application.