Owen Tak-Yin Tsang

TL;DR: In the peripheral blood mononuclear cells of COVID-19 patients, the authors observed reduced expression of human leukocyte antigen class DR (HLA-DR) and proinflammatory cytokines by myeloid cells as well as impaired mammalian target of rapamycin (mTOR) signaling and interferon-α (IFN-α) production by plasmacytoid dendritic cells.

TL;DR: Investigating 17 acute and 24 convalescent patients found that acute SARS-CoV-2 infection resulted in broad immune cell reduction including T, NK, monocyte and dendritic cell (DC) and DCs were significantly reduced with functional impairment, and cDC:pDC ratios were increased among acute severe patients.

TL;DR: appropriate hospital infection control measures was able to prevent nosocomial transmission of SARS-CoV-2, and early airborne infection isolation, rapid molecular diagnostic testing, and contact tracing for healthcare workers with unprotected exposure in the hospitals was implemented.

TL;DR: Analysis of plasma from patients infected by SARS-CoV-2 or SARV, and from infected or immunized mice shows cross-reactivity in antibody binding to the spike protein is common, but cross-neutralization of the live viruses may be rare, indicating the presence of non-neutralizing antibody response to conserved epitopes in the spike.

TL;DR: Using IgG ELISA based on the RBD of the spike protein to screen sera for SARS-CoV-2 antibody, followed by confirmation using PRNT90, is a valid approach for large-scale sero-epidemiology studies.