A
Atsushi Kawaguchi
Researcher at University of Tsukuba
Publications - 57
Citations - 2506
Atsushi Kawaguchi is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Virus & RNA-dependent RNA polymerase. The author has an hindex of 20, co-authored 48 publications receiving 2096 citations. Previous affiliations of Atsushi Kawaguchi include Yokohama City University & Kitasato University.
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Journal ArticleDOI
Long Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune Stimuli
Katsutoshi Imamura,Naoto Imamachi,Gen Akizuki,Michiko Kumakura,Atsushi Kawaguchi,Kyosuke Nagata,Akihisa Kato,Yasushi Kawaguchi,Hiroki Sato,Misako Yoneda,Chieko Kai,Tetsushi Yada,Yutaka Suzuki,Toshimichi Yamada,Takeaki Ozawa,Kiyomi Kaneki,Tsuyoshi Inoue,Mika Kobayashi,Tatsuhiko Kodama,Youichiro Wada,Kazuhisa Sekimizu,Nobuyoshi Akimitsu +21 more
TL;DR: Nuclear enriched abundant transcript 1 (NEAT1), an essential lncRNA for the formation of nuclear body paraspeckles, is induced by influenza virus and herpes simplex virus infection as well as by Toll-like receptor3-p38 pathway-triggered poly I:C stimulation, resulting in excess formation of paraspeakles.
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The structural basis for an essential subunit interaction in influenza virus RNA polymerase
Eiji Obayashi,Hisashi Yoshida,Fumihiro Kawai,Naoya Shibayama,Atsushi Kawaguchi,Kyosuke Nagata,Jeremy R. H. Tame,Sam-Yong Park +7 more
TL;DR: It is demonstrated the importance to viral replication of a subunit interface in the viral RNA polymerase, thereby providing a new set of potential drug binding sites entirely independent of surface antigen type.
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Involvement of Hsp90 in Assembly and Nuclear Import of Influenza Virus RNA Polymerase Subunits
TL;DR: The results suggest that Hsp90 is involved in the assembly and nuclear transport of viral RNA polymerase subunits, possibly as a molecular chaperone for the polymer enzyme subunits prior to the formation of a mature ternary polymerase complex.
Journal ArticleDOI
Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase
Kanako Sugiyama,Eiji Obayashi,Atsushi Kawaguchi,Yukari Suzuki,Jeremy R. H. Tame,Kyosuke Nagata,Sam-Yong Park +6 more
TL;DR: This novel interface is surprisingly small, yet, it has a crucial function in regulating the 250 kDa polymerase complex and is completely conserved among avian and human influenza viruses.
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Apical transport of influenza A virus ribonucleoprotein requires Rab11-positive recycling endosome.
Fumitaka Momose,Tetsuya Sekimoto,Takashi Ohkura,Shuichi Jo,Atsushi Kawaguchi,Atsushi Kawaguchi,Kyosuke Nagata,Yuko Morikawa +7 more
TL;DR: Results suggest that the progeny vRNP makes use of Rab11-dependent RE machinery for APM trafficking, suggesting that Influenza A virus RNA genome exists as eight-segmented ribonucleoprotein complexes containing viral RNA polymerase and nucleoprotein.