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Atsushi Toyoshima
Researcher at Osaka University
Publications - 103
Citations - 1471
Atsushi Toyoshima is an academic researcher from Osaka University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 17, co-authored 91 publications receiving 1022 citations. Previous affiliations of Atsushi Toyoshima include Japan Atomic Energy Agency & Japan Atomic Energy Research Institute.
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Journal ArticleDOI
Theranostics Targeting Fibroblast Activation Protein in the Tumor Stroma: 64Cu- and 225Ac-Labeled FAPI-04 in Pancreatic Cancer Xenograft Mouse Models
Tadashi Watabe,Yuwei Liu,Kazuko Kaneda-Nakashima,Yoshifumi Shirakami,Thomas Lindner,Kazuhiro Ooe,Atsushi Toyoshima,Kojiro Nagata,Eku Shimosegawa,Uwe Haberkorn,Clemens Kratochwil,Atsushi Shinohara,Frederik L. Giesel,Frederik L. Giesel,Jun Hatazawa +14 more
TL;DR: This proof-of-concept study showed that 64Cu-FAPI-04 and 225Ac-F API-04 could be used in theranostics for the treatment of FAP-expressing pancreatic cancer and will contribute to the development of a new treatment strategy.
Journal ArticleDOI
Measurement of the first ionization potential of lawrencium, element 103
Tetsuya Sato,Masato Asai,Anastasia Borschevsky,Thierry Stora,Nozomi Sato,Y. Kaneya,Y. Kaneya,Kazuaki Tsukada,Ch. E. Düllmann,Klaus Eberhardt,Ephraim Eliav,Shinichi Ichikawa,Uzi Kaldor,J. V. Kratz,Sunao Miyashita,Y. Nagame,Y. Nagame,Kazuhiro Ooe,Akihiko Osa,D. Renisch,Jörg Runke,Matthias Schädel,Petra Thörle-Pospiech,Atsushi Toyoshima,Norbert Trautmann +24 more
TL;DR: The present work provides a reliable benchmark for theoretical calculations and also opens the way for IP1 measurements of superheavy elements (that is, transactinides) on an atom-at-a-time scale.
Journal ArticleDOI
Synthesis and detection of a seaborgium carbonyl complex
Julia Even,Alexander Yakushev,Ch. E. Düllmann,H. Haba,Masato Asai,Tetsuya Sato,H. Brand,A. Di Nitto,Robert Eichler,Robert Eichler,Fangli Fan,W. Hartmann,M. Huang,Egon Jäger,Daiya Kaji,J. Kanaya,Y. Kaneya,Jadambaa Khuyagbaatar,Birgit Kindler,J. V. Kratz,J. Krier,Y. Kudou,N. Kurz,Bettina Lommel,Sunao Miyashita,Sunao Miyashita,K. Morimoto,Kosuke Morita,Masashi Murakami,Y. Nagame,Heino Nitsche,Heino Nitsche,Kazuhiro Ooe,Zhi Qin,Matthias Schädel,J. Steiner,Takayuki Sumita,Mirei Takeyama,K. Tanaka,Atsushi Toyoshima,Kazuaki Tsukada,Andreas Türler,Andreas Türler,I. Usoltsev,I. Usoltsev,Yasuo Wakabayashi,Yuezhao Wang,Norbert Wiehl,S. Yamaki +48 more
TL;DR: A gas-phase carbonylation technique previously tested on short-lived molybdenum and tungsten isotopes was applied to the preparation of a carbonyl complex of seaborgium, the 106th element, and it was concluded that hexacarbonyl Sg(CO)6 was the most likely structural formula.
Journal ArticleDOI
Fibroblast Activation Protein Targeted Therapy Using [177Lu]FAPI-46 Compared with [225Ac]FAPI-46 in a Pancreatic Cancer Model
Yuwei Liu,Tadashi Watabe,Kazuko Kaneda-Nakashima,Yoshifumi Shirakami,Sadahiro Naka,Kazuhiro Ooe,Atsushi Toyoshima,Kojiro Nagata,Uwe Haberkorn,Clemens Kratochwil,Atsushi Shinohara,Jun Hatazawa,Frederik L. Giesel,Frederik L. Giesel +13 more
TL;DR: The dose-dependent tumour-suppressive effect of [177Lu]FAPI-46 and [225Ac]F API-46 suggested promising application in FAP-expressing pancreatic cancer.
Journal ArticleDOI
Enhancement of 211At Uptake via the Sodium Iodide Symporter by the Addition of Ascorbic Acid in Targeted α-Therapy of Thyroid Cancer
Tadashi Watabe,Kazuko Kaneda-Nakashima,Yuwei Liu,Yoshifumi Shirakami,Kazuhiro Ooe,Atsushi Toyoshima,Eku Shimosegawa,Mitsuhiro Fukuda,Atsushi Shinohara,Jun Hatazawa +9 more
TL;DR: Uptake of 211At was enhanced in differentiated thyroid cancer cells as well as the normal thyroid using 211At solution treated with AA, and showed dose-dependent efficacy against the K1-NIS xenografts, suggesting its potential applicability to targeted α-therapy.