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Audrey Carriere
Researcher at Université de Montréal
Publications - 6
Citations - 1420
Audrey Carriere is an academic researcher from Université de Montréal. The author has contributed to research in topics: Phosphorylation & MAPK/ERK pathway. The author has an hindex of 6, co-authored 6 publications receiving 1301 citations.
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Journal ArticleDOI
mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
TL;DR: It is shown that growth factors promote the phosphorylation of Rictor (rapamycin-insensitive companion of mTOR), an essential subunit of m TORC2, and a new regulatory link between the two mTOR complexes is uncovered, whereby RictOr integrates mTORC1-dependent signaling.
Journal ArticleDOI
Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation
Audrey Carriere,Marie Cargnello,Louis-André Julien,Huanhuan Gao,Eric Bonneil,Pierre Thibault,Philippe P. Roux +6 more
TL;DR: A unique mode of mTOR regulation is proposed in which RSK-mediated phosphorylation of Raptor regulates mTORC1 activity and thus suggest a means by which the Ras/MAPK pathway might promote rapamycin-sensitive signaling independently of the PI3K/Akt pathway.
Journal ArticleDOI
ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)
Audrey Carriere,Yves Romeo,Hugo A. Acosta-Jaquez,Julie Moreau,Eric Bonneil,Pierre Thibault,Diane C. Fingar,Philippe P. Roux +7 more
TL;DR: The data provide a novel regulatory mechanism by which mitogenic and oncogenic activation of the Ras/MAPK pathway promotes mTOR signaling, and three proline-directed residues within Raptor, Ser8, Ser696, and Ser863, which are directly phosphorylated by ERK1/2 are found.
Journal ArticleDOI
The RSK factors of activating the Ras/MAPK signaling cascade.
TL;DR: The upregulation of RSK1 and RSK2 expression in different types of cancer suggest that they may be involved in oncogenesis and could potentially be targeted in anti-cancer therapies.
Journal ArticleDOI
Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863 and Multisite Phosphorylation
Kathryn G. Foster,Hugo A. Acosta-Jaquez,Yves Romeo,Bilgen Ekim,Ghada A. Soliman,Audrey Carriere,Philippe P. Roux,Bryan A. Ballif,Diance C. Fingar +8 more
TL;DR: It is reported that insulin promotes mTORC1-associated phosphorylation of raptor Ser863 via the canonical PI3K/TSC/Rheb pathway in a rapamycin-sensitive manner.