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Pierre Thibault
Researcher at Université de Montréal
Publications - 368
Citations - 19629
Pierre Thibault is an academic researcher from Université de Montréal. The author has contributed to research in topics: Mass spectrometry & SUMO protein. The author has an hindex of 77, co-authored 332 publications receiving 17741 citations. Previous affiliations of Pierre Thibault include Halifax & Queen's University.
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Journal ArticleDOI
Phagosomes are competent organelles for antigen cross-presentation
Mathieu Houde,Sylvie Bertholet,Etienne Gagnon,Sylvain Brunet,Guillaume Goyette,Annie Laplante,Michael F. Princiotta,Pierre Thibault,David B. Sacks,Michel Desjardins +9 more
TL;DR: It is shown that phagosomes display the elements and properties needed to be self-sufficient for the cross-presentation of exogenous antigens, a newly ascribed function linked to phagocytosis mediated by the endoplasmic reticulum.
Journal ArticleDOI
Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.
Tiffany N. Seagroves,Heather E. Ryan,Han Lu,Bradly G. Wouters,Merrill Knapp,Pierre Thibault,Keith R. Laderoute,Randall S. Johnson +7 more
TL;DR: HIF-1 activation is an essential control element of the metabolic state during hypoxia; this requirement has important implications for the regulation of cell growth during development, angiogenesis, and vascular injury.
Journal ArticleDOI
Identification of domoic acid, a neuroexcitatory amino acid, in toxic mussels from eastern Prince Edward Island
Jeffrey L. C. Wright,Robert K. Boyd,A. S. W. de Freitas,Michael L. Falk,R. A. Foxall,W. D. Jamieson,Maurice V. Laycock,A. W. Mcculloch,A. G. McInnes,P. Odense,V. P. Pathak,Michael A. Quilliam,Mark A. Ragan,P. G. Sim,Pierre Thibault,John A. Walter,M. Gilgan,D. J. A. Richard,D. Dewar +18 more
TL;DR: The causative agent of toxicity in cultured mussels from a localized area of eastern Prince Edward Island has been identified as domoic acid, a neuroexcitatory amino acid.
Journal ArticleDOI
Identification of the Carbohydrate Moieties and Glycosylation Motifs in Campylobacter jejuni Flagellin
Pierre Thibault,Susan M. Logan,John F. Kelly,Jean-Robert Brisson,Cheryl P. Ewing,Trevor J. Trust,Patricia Guerry +6 more
TL;DR: Glycosylation is not random, since 19 of the total 107 Ser/Thr residues are modified, and all but one of these are restricted to the central, surface-exposed domain of flagellin when folded in the filament.
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Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation
Audrey Carriere,Marie Cargnello,Louis-André Julien,Huanhuan Gao,Eric Bonneil,Pierre Thibault,Philippe P. Roux +6 more
TL;DR: A unique mode of mTOR regulation is proposed in which RSK-mediated phosphorylation of Raptor regulates mTORC1 activity and thus suggest a means by which the Ras/MAPK pathway might promote rapamycin-sensitive signaling independently of the PI3K/Akt pathway.