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Ava E. Brent
Researcher at New York University
Publications - 15
Citations - 2545
Ava E. Brent is an academic researcher from New York University. The author has contributed to research in topics: Tendon formation & Myotome. The author has an hindex of 11, co-authored 13 publications receiving 2343 citations. Previous affiliations of Ava E. Brent include Harvard University.
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Journal ArticleDOI
Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments
Ronen Schweitzer,Jay H. Chyung,Lewis C. Murtaugh,Ava E. Brent,Vicki Rosen,Eric N. Olson,Andrew B. Lassar,Clifford J. Tabin +7 more
TL;DR: Scleraxis, a bHLH transcription factor, is a highly specific marker for all the connective tissues that mediate attachment of muscle to bone in chick and mouse, including the limb tendons, and it is shown that early scleraxis expression marks the progenitor cell populations for these tissues.
Journal ArticleDOI
A Somitic Compartment of Tendon Progenitors
TL;DR: It is demonstrated that the tendons associated with the axial skeleton derive from a heretofore unappreciated, fourth compartment of the somites, and may reveal a general mechanism for the specification of other somitic subcompartments.
Journal ArticleDOI
Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene
Brian A. Pryce,Ava E. Brent,Nicholas D. Murchison,Clifford J. Tabin,Ronen Schweitzer,Ronen Schweitzer +5 more
TL;DR: Two different transgene reporters are generated, alkaline phosphatase (AP) and green fluorescent protein (GFP), each expressed using regulatory elements derived from the endogenous Scleraxis (Scx) locus, which will facilitate isolation of tendon cells and phenotypic analysis of these tissues in a variety of genetic backgrounds.
Journal ArticleDOI
FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression
Ava E. Brent,Clifford J. Tabin +1 more
TL;DR: It is proposed that the domain of the somitic tendon progenitors is regulated both by the restricted expression of Pea3 and Erm, and by the precise spatial relationship between these Ets transcription factors and the FGF signal originating in the myotome.
Journal ArticleDOI
Developmental regulation of somite derivatives: muscle, cartilage and tendon.
Ava E. Brent,Clifford J. Tabin +1 more
TL;DR: The specification of somite derivatives involves the action of patterning signals secreted from adjacent tissue combined with the activation, in particular somitic compartments, of genes promoting cell lineage specification.