C
Clifford J. Tabin
Researcher at Harvard University
Publications - 292
Citations - 52787
Clifford J. Tabin is an academic researcher from Harvard University. The author has contributed to research in topics: Limb bud & Limb development. The author has an hindex of 113, co-authored 288 publications receiving 49470 citations. Previous affiliations of Clifford J. Tabin include Eckerd College & Massachusetts Institute of Technology.
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Journal ArticleDOI
Sonic Hedgehog Mediates the Polarizing Activity of the ZPA
TL;DR: A vertebrate gene related to the Drosophila segment polarity gene hedgehog, which is expressed specifically in the ZPA and in other regions of the embryo, that is capable of polarizing limbs in grafting experiments is isolated.
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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
Annie Yang,Ronen Schweitzer,Deqin Sun,Mourad Kaghad,Nancy Walker,Roderick T. Bronson,Clifford J. Tabin,Arlene H. Sharpe,Daniel Caput,Christopher P. Crum,Frank McKeon +10 more
TL;DR: It is reported that mice homozygous for a disrupted p63 gene have major defects in their limb, craniofacial and epithelial development, and results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelialDevelopment and morphogenesis.
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Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
Andrea Vortkamp,Kaechoong Lee,Beate Lanske,Gino V. Segre,Henry M. Kronenberg,Clifford J. Tabin +5 more
TL;DR: In vitro application of Hedgehog or P THrP protein to normal or PTHrP (−/−) limb explants demonstrated that PTHRP mediates the effects of Ihh through the formation of a negative feedback loop that modulates the rate of chondrocyte differentiation.
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Mechanism of activation of a human oncogene.
Clifford J. Tabin,Scott M. Bradley,Cornelia I. Bargmann,Robert A. Weinberg,Alex G. Papageorge,Edward M. Scolnick,Ravi Dhar,Douglas R. Lowy,Esther H. Chang,Esther H. Chang +9 more
TL;DR: Experiments are presented that localize the genetic lesion that led to activation of the oncogene that affects the structure of theOncogene-encoded protein.
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Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities
TL;DR: The zone of polarizing activity (ZPA) in the posterior limb bud produces Sonic Hedgehog (Shh) protein, which plays a critical role in establishing distinct fates along the anterior-posterior axis, and recombinase base mapping in the mouse determines the ultimate fate of the Shh-producing cells.