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Ava Hosseinzadeh
Researcher at Umeå University
Publications - 12
Citations - 377
Ava Hosseinzadeh is an academic researcher from Umeå University. The author has contributed to research in topics: Neutrophil extracellular traps & Innate immune system. The author has an hindex of 7, co-authored 12 publications receiving 306 citations.
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Journal ArticleDOI
Nicotine induces neutrophil extracellular traps
TL;DR: It is reported that nicotine induces neutrophils to release NETs in a dose‐dependent manner, which may in turn contribute to smoking‐related diseases.
Journal ArticleDOI
Vibrio cholerae evades neutrophil extracellular traps by the activity of two extracellular nucleases.
Andrea Seper,Ava Hosseinzadeh,Gregor Gorkiewicz,Sabine Lichtenegger,Sandro Roier,Deborah R. Leitner,Marc Röhm,Andreas Grutsch,Joachim Reidl,Constantin F. Urban,Stefan Schild +10 more
TL;DR: A first comprehensive characterization of the interplay between neutrophils and V. cholerae is provided along with new evidence that the innate immune response impacts the colonization of V.Cholerae in vivo, which may enhance survival fitness of the pathogen through NET degradation.
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Stable Redox-Cycling Nitroxide Tempol Inhibits NET Formation.
TL;DR: In this article, the effect of 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) on NET formation triggered by phorbol esters and Candida albicans was investigated.
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Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity
Saskia F. Erttmann,Anetta Härtlova,Marta Sloniecka,Faizal A.M. Raffi,Ava Hosseinzadeh,Tomas Edgren,Reza Rofougaran,Ulrike Resch,Maria Fällman,Torben Ek,Nelson O. Gekara +10 more
TL;DR: An unanticipated function of reactive oxygen species (ROS) in negative regulation of inflammasomes is revealed and a theory for the notable susceptibility of AT patients to pulmonary bacterial infection is proposed.
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Role of YopK in Yersinia pseudotuberculosis Resistance against Polymorphonuclear Leukocyte Defense
Sara E. Thorslund,David Ermert,Anna Fahlgren,Saskia F. Erttmann,Kristina Nilsson,Ava Hosseinzadeh,Constantin F. Urban,Maria Fällman +7 more
TL;DR: It is shown that the virulence protein YopK has a role in the mechanism by which Y. pseudotuberculosis avoids the polymorphonuclear leukocyte or neutrophil (PMN) defense, and a mechanism wherebyYopK functions to prevent unintended Yop delivery and thereby PMN disruption, resulting in necrosis-like cell death, which would enhance the inflammatory response favoring the host.