Sandro Roier

TL;DR: The results suggest a new general mechanism of OMV biogenesis based on phospholipid accumulation in the outer leaflet of the outer membrane, which is highly conserved among Gram-negative bacteria, provides a means for regulation, can account for OMV formation under all growth conditions, and might have important pathophysiological roles in vivo.

TL;DR: Extracellular DNA is identified and characterized as a component of the Vibrio biofilm matrix and it is shown that extracellularDNA is modulated and controlled by the two ext racellular nucleases Dns and Xds.

TL;DR: A first comprehensive characterization of the interplay between neutrophils and V. cholerae is provided along with new evidence that the innate immune response impacts the colonization of V.Cholerae in vivo, which may enhance survival fitness of the pathogen through NET degradation.

TL;DR: It is shown that a pyrrolobenzodiazepine metabolite produced by Klebsiella oxytoca directly damages the intestinal epithelium and disrupts its protective barrier function, and the enterotoxicity of tilivalline provides a mechanism for antibiotic-induced colitis.

TL;DR: It is demonstrated that an intranasal immunization with NTHi OMVs results in a robust and complex humoral and mucosal immune response, and indicates that OMVs derived from Nthi strains have a high potential to act as a vaccine against NTHo infections.