A
Axel Knebel
Researcher at University of Dundee
Publications - 78
Citations - 6620
Axel Knebel is an academic researcher from University of Dundee. The author has contributed to research in topics: Ubiquitin & Ubiquitin ligase. The author has an hindex of 39, co-authored 72 publications receiving 5524 citations.
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The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.
TL;DR: The results suggest that CapZIP may be phosphorylated by JNK (c-Jun N-terminal kinase), which phosphorylates CapZip to >5 mol/mol within minutes within minutes in vitro.
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A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs.
TL;DR: It is suggested that SAKS1 may be an adaptor that directs VCP to polyubiquitinated proteins, and PNGase to misfolded glycoproteins, facilitating their destruction by the proteasome.
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UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation
TL;DR: This study shows that independently of its function as a ubiquitin-binding adaptor for p97, UBXN7 directly interacts with neddylated cullins and causes the accumulation of the CUL2 substrate HIF1α.
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Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization
Julia Madrzak,Marc Fiedler,Christopher M. Johnson,Richard Ewan,Axel Knebel,Mariann Bienz,Jason W. Chin +6 more
TL;DR: It is shown that the ubiquitination of DIX at K54 blocks its polymerization in solution, whereas DIX58-Ub remains oligomerization-competent, rather than antagonize it as previously thought for CYLD.
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Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3).
Lisa Logie,Lidy van Aalten,Axel Knebel,Thomas Force,C. James Hastie,Hilary MacLauchlan,David G. Campbell,Robert Gourlay,Alan R. Prescott,Jane Davidson,William Fuller,Calum Sutherland +11 more
TL;DR: The work presented identifies RABEP2 as a novel primed substrate of GSK3, and thus a potential biomarker for G SK3 activity, but understanding how phosphorylation regulates RAB EP2 function requires more information on physiological roles of RABep2.