Axel Knebel

TL;DR: It is demonstrated that the components of CRL5SOCS2 can be specifically pulled from K562 human cell lysates using beads decorated with phosphorylated growth hormone receptor peptides, and a structural model for full-size neddylated and unneddylated CRL3-Rbx2 complexes is supported by traveling wave ion mobility mass spectrometry data.

TL;DR: Results indicate that contraction-induced phosphorylation is probably catalyzed by MLCK and not MAPKAP-K2, and that an arginine located three residues N-terminal to the site of phosphorylated was thought to be critical for the specificity of MAPK AP-K1.

TL;DR: Although accurate determinations of low-dose inductions have not been achieved for technical reasons, the dose-response curves of induced signal transduction likely show threshold characteristics, in contrast to the direct consequences of DNA damage.

TL;DR: Some of the methodology that has been employed to study radiation-induced signaling and that led to the recognition of radiation- induced pathways and of some of the primary target molecules are addressed.

TL;DR: This work characterize biocompatible chemistry that enables sequential functionalization of cysteines within proteins at a single atomic center and develops a new class of activity-based probe that profiles transthiolation activity of human E1 activating enzymes.