A
Axel Knebel
Researcher at University of Dundee
Publications - 78
Citations - 6620
Axel Knebel is an academic researcher from University of Dundee. The author has contributed to research in topics: Ubiquitin & Ubiquitin ligase. The author has an hindex of 39, co-authored 72 publications receiving 5524 citations.
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Journal ArticleDOI
Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.
TL;DR: In this paper, the authors found that DCN-like enzymes form stable stoichiometric complexes with CAND1 and cullins that can only be neddylated in the presence of a substrate adaptor.
Peer ReviewDOI
Author response: PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
Kerryn Berndsen,Pawel Lis,Wondwossen M Yeshaw,Paulina S. Wawro,Raja Sekhar Nirujogi,Melanie Wightman,Thomas Macartney,Mark Dorward,Axel Knebel,Francesca Tonelli,Suzanne R. Pfeffer,Dario R. Alessi +11 more
Journal ArticleDOI
RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation.
Francisco Bustos,Anna Segarra-Fas,Viduth K. Chaugule,Lennart Brandenburg,Emma Branigan,Rachel Toth,Thomas Macartney,Axel Knebel,Ronald T. Hay,Helen Walden,Greg M. Findlay +10 more
TL;DR: An embryonic stem cell model is employed to explore developmental functions of a recently identified XLID gene, the RNF12/RLIM E3 ubiquitin ligase, and shows that RNF 12 catalytic activity is required for proper stem cell maintenance and neural differentiation, and this is disrupted by patient-associated XLID mutation.
Journal ArticleDOI
High-throughput matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry–based deubiquitylating enzyme assay for drug discovery
Virginia De Cesare,Jennifer Moran,Ryan Traynor,Axel Knebel,Maria Stella Ritorto,Matthias Trost,Matthias Trost,Hilary McLauchlan,C. James Hastie,Paul Davies +9 more
TL;DR: The HT adaptation of the previously published MALDI-TOF-based DUB assay method is presented, which quantitates the amount of mono-ubiquitin generated by the in vitro cleavage of ubiquitin chains by DUBs.
Journal ArticleDOI
Regulation of Microfilament Organization by Kaposi Sarcoma-associated Herpes Virus-cyclin·CDK6 Phosphorylation of Caldesmon *
Maria Emanuela Cuomo,Axel Knebel,Georgina M. Platt,Nick Morrice,Philip Cohen,Sibylle Mittnacht +5 more
TL;DR: The identification of the actin- and calmodulin-binding protein caldesmon (CALD1) as a novel K-cyclin·CDK substrate, which is not phosphorylation defective CALD1, establishes a novel link between KSHV infection and the regulation of theActin cytoskeleton.