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Ayca Arslan-Ergul
Researcher at Bilkent University
Publications - 13
Citations - 409
Ayca Arslan-Ergul is an academic researcher from Bilkent University. The author has contributed to research in topics: Senescence & Telomere. The author has an hindex of 8, co-authored 12 publications receiving 343 citations. Previous affiliations of Ayca Arslan-Ergul include Hacettepe University & Strathclyde Institute of Pharmacy and Biomedical Sciences.
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Journal ArticleDOI
Senescence and immortality in hepatocellular carcinoma
Mehmet Ozturk,Ayca Arslan-Ergul,Sevgi Bagislar,Sevgi Bagislar,Serif Senturk,Haluk Yuzugullu,Haluk Yuzugullu +6 more
TL;DR: Hepatocellular carcinoma (HCC) cells display inactivating mutations of p53 and epigenetic silencing of p16(INK4a), and they re-express telomerase reverse transcriptase required for telomere maintenance, likely to contribute significantly to HCC development.
Journal ArticleDOI
Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells.
Nuri Ozturk,Esra Erdal,Mine Mumcuoglu,Kamil Can Akcali,Ozden Yalcin,Serif Senturk,Ayca Arslan-Ergul,Bala Gur,Isik G. Yulug,Rengul Cetin-Atalay,Cengiz Yakicier,Tamer Yagci,Mesut Tez,Mehmet Ozturk +13 more
TL;DR: The spontaneous induction of replicative senescence is shown in p53-and p16INK4a-deficient hepatocellular carcinoma cells by short hairpin RNA-mediated SIP1 inactivation released hTERT repression and rescued clonal hepatocells from senescences arrest.
Journal ArticleDOI
Genome-Wide Transcriptional Reorganization Associated with Senescence-to-Immortality Switch during Human Hepatocellular Carcinogenesis
Gokhan Yildiz,Ayca Arslan-Ergul,Sevgi Bagislar,Sevgi Bagislar,Ozlen Konu,Haluk Yuzugullu,Haluk Yuzugullu,Ozge Gursoy-Yuzugullu,Ozge Gursoy-Yuzugullu,Nuri Ozturk,Cigdem Ozen,Hilal Özdağ,Esra Erdal,Sedat Karademir,Ozgul Sagol,Dilsa Mizrak,Hakan Bozkaya,Hakki Gokhan Ilk,Ozlem Ilk,Biter Bilen,Rengul Cetin-Atalay,Nejat Akar,Mehmet Ozturk,Mehmet Ozturk +23 more
TL;DR: It is demonstrated that senescence bypass plays a central role in hepatocellular carcinogenesis engendering systematic changes in the transcription of genes regulating DNA repair, proliferation, differentiation and metabolism.
Journal ArticleDOI
Gene expression changes in aging Zebrafish (Danio rerio) brains are sexually dimorphic
TL;DR: In the brains of young and old male and female zebrafish there were over 500 differentially expressed genes associated with multiple pathways but most notably were those related to neurogenesis and cell differentiation, as well as brain and nervous system development.
Journal ArticleDOI
Short-term dietary restriction in old zebrafish changes cell senescence mechanisms.
TL;DR: The results suggest that the potential effects of DR could be mediated by telomere regulation and whether these are beneficial or negative remains to be determined.