N
Nejat Akar
Researcher at TOBB University of Economics and Technology
Publications - 414
Citations - 6602
Nejat Akar is an academic researcher from TOBB University of Economics and Technology. The author has contributed to research in topics: Population & Factor V. The author has an hindex of 39, co-authored 406 publications receiving 6271 citations. Previous affiliations of Nejat Akar include Ankara University & Virginia Commonwealth University.
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Journal ArticleDOI
Phylogeographic Analysis of Haplogroup E3b (E-M215) Y Chromosomes Reveals Multiple Migratory Events Within and Out Of Africa
Fulvio Cruciani,Roberta La Fratta,P Santolamazza,Daniele Sellitto,Roberto Pascone,Pedro Moral,Elizabeth Watson,Valentina Guida,Eliane Beraud Colomb,Boriana Zaharova,João Lavinha,Giuseppe Vona,Rashid Aman,Francesco Calì,Nejat Akar,Martin B. Richards,Antonio Torroni,Andrea Novelletto,Rosaria Scozzari +18 more
TL;DR: The present study shows that earlier work based on fewer Y-chromosome markers led to rather simple historical interpretations and highlights the fact that many population-genetic analyses are not robust to a poorly resolved phylogeny and reveals signatures of several distinct processes of migrations and/or recurrent gene flow that occurred in Africa and western Eurasia over the past 25000 years.
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A degradation-sensitive anionic trypsinogen ( PRSS2 ) variant protects against chronic pancreatitis
Heiko Witt,Miklós Sahin-Tóth,Olfert Landt,Jian-Min Chen,Thilo Kähne,Joost P.H. Drenth,Zoltán Kukor,Edit Szepessy,Walter Halangk,Stefan Dahm,Klaus Rohde,Hans Ulrich Schulz,Cédric Le Maréchal,Nejat Akar,Rudolf W. Ammann,Kaspar Truninger,Mario Bargetzi,Eesh Bhatia,Carlo Castellani,Giulia Martina Cavestro,Milos Cerny,Giovanni Destro-Bisol,Gabriella Spedini,Hans Eiberg,Jan B.M.J. Jansen,Monika Koudova,Eva Rausova,Milan Macek,Núria Malats,Francisco X. Real,Hans Jürgen Menzel,Pedro Moral,Roberta Galavotti,Pier Franco Pignatti,Olga Rickards,Julius Spicak,Narcis O. Zarnescu,Wolfgang Böck,Thomas M. Gress,Helmut Friess,Johann Ockenga,Hartmut Schmidt,Roland H. Pfützer,Matthias Löhr,Peter Simon,Frank Ulrich Weiss,Markus M. Lerch,Niels Teich,Volker Keim,Thomas Berg,Bertram Wiedenmann,W Luck,David A. Groneberg,Michael Becker,Thomas Keil,Andreas Kage,Jana Bernardova,Markus Braun,Claudia Güldner,J. Halangk,Jonas Rosendahl,Ulrike Witt,Matthias Treiber,Renate Nickel,Claude Férec +64 more
TL;DR: The G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis.
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Genotype–phenotype correlation in a large group of Turkish patients with familial Mediterranean fever: evidence for mutation-independent amyloidosis
Fatoş Yalçınkaya,Nilgün Çakar,M. Misirlioglu,Necmiye Tümer,Nejat Akar,Mustafa Tekin,Hakkı Taştan,Hulusi Koçak,Nuray Özkaya,Atilla Halil Elhan +9 more
TL;DR: None of the four missense mutations is associated with a severe disease or the development of amyloidosis in Turkish FMF patients living in Turkey.
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Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls
Benedetto Simone,Valerio De Stefano,Emanuele Leoncini,Jeppe Zacho,Ida Martinelli,Joseph Emmerich,Elena Rossi,Aaron R. Folsom,Wassim Y. Almawi,Pierre Y. Scarabin,Martin den Heijer,Mary Cushman,Silvana Penco,Amparo Vayá,Pantep Angchaisuksiri,Gulfer Okumus,Donato Gemmati,Simona Cima,Nejat Akar,Kıvılcım Oğuzülgen,Véronique Ducros,Christoph Lichy,Consuelo Fernandez-Miranda,Andrzej Szczeklik,José A. Nieto,José Domingo Torres,Véronique Le Cam-Duchez,Petar Ivanov,Carlos Cantu-Brito,Veronika M. Shmeleva,Mojka Stegnar,Dotun Ogunyemi,Suhair S Eid,Nicola Nicolotti,Emma De Feo,Walter Ricciardi,Stefania Boccia +36 more
TL;DR: In this large pooled analysis of case–control and cohort studies investigating in adults the association between each variant and VTE, no effect was found for C677T MTHFR on VTE; FVL and PT20210A were confirmed to be moderate risk factors.
Journal ArticleDOI
Y chromosomal haplogroup J as a signature of the post-neolithic colonization of Europe
F. Di Giacomo,Francesca Luca,Luis Ovidiu Popa,Nejat Akar,Nicholas P. Anagnou,J. Banyko,Radim Brdicka,Guido Barbujani,F. Papola,G. Ciavarella,F. Cucci,L. Di Stasi,Lucian Gavrila,M. G. Kerimova,D. Kovatchev,A. I. Kozlov,Aphrodite Loutradis,V. Mandarino,C. Mammi,E. N. Michalodimitrakis,E. N. Michalodimitrakis,Giorgio Paoli,Kalliopi I. Pappa,G. Pedicini,L. Terrenato,Sergio Tofanelli,Patrizia Malaspina,Andrea Novelletto +27 more
TL;DR: Dating estimates confirmed the presence of a major population structuring at the time of spread of haplogroup J in Europe and a punctuation in the peopling of this continent in the post-Neolithic, compatible with the expansion of the Greek world.