Ayleen Fernández-Fierro

TL;DR: BCG-induced cross-protection and acquisition of trained immunity and potential heterologous effects of recombinant BCG vaccines are discussed.

TL;DR: It is concluded that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health and opens a new outlook on the investigation of naturally derivedHO-1 inducers, mainly concerning autoimmunity.

TL;DR: The clinical relevance of tolDC generation with CoPP, dexamethasone and rosiglitazone and the use of these modified cells as a therapy for systemic autoimmunity is strengthened.

TL;DR: It is found that hRSV infection alters the permeability of the blood-brain barrier (BBB) in mice, allowing the trespassing of macromolecules and immune cells and leading to increased infiltration of immune cells into the CNS together with an increased expression of pro-inflammatory cytokines in the brain.

TL;DR: The heme oxygenase (HO) system involves three isoforms of this enzyme, HO-1,HO-2, and HO-3 as discussed by the authors, which display the same catalytic activity, oxidating the heme group to produce biliverdin, ferrous iron, and carbon monoxide (CO).