Ayman Koteish

TL;DR: The results extend previous national estimates of the prevalence of NAFLD in the US population and highlight the burden of this disease, which is more common in men, Mexican Americans, and people with diabetes and obesity are the most affected groups.

TL;DR: Animals with genetic or environmental induction of hepatic lipogenesis appear to be useful models for human nonalcoholic fatty liver disease in which hyperinsulinemia and defective leptin signaling are conspicuous at early stages of the disease process.

TL;DR: It is shown that TGF-β1 induces an epithelial-to-mesenchymal transition (EMT) state in mature hepatocytes in vitro, and a potentially crucial role for EMT in the development and progression of hepatic fibrogenesis is supported.

TL;DR: It is reported that the hepatocyte proliferative response to partial liver resection is severely inhibited in transgenic mice with targeted disruption of the iNOS gene, suggesting that during successful tissue regeneration, injury-related cytokines induce factors, such as iN OS and its product, NO, that protect surviving cells from cytokine-mediated death.

TL;DR: Non‐alcoholic fatty liver disease (NAFLD) is a highly prevalent condition and emerging evidence suggests that vitamin D may play a role in the pathogenesis of NAFLD.