J
James J. Potter
Researcher at Johns Hopkins University School of Medicine
Publications - 116
Citations - 5277
James J. Potter is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Hepatic stellate cell & Alcohol dehydrogenase. The author has an hindex of 35, co-authored 113 publications receiving 4859 citations. Previous affiliations of James J. Potter include Johns Hopkins University & Veterans Health Administration.
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Journal ArticleDOI
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis
Feng Li,Yunyue Wang,Karen I. Zeller,James J. Potter,Diane R. Wonsey,Kathryn A. O'Donnell,Jung Whan Kim,Jason T. Yustein,Linda A. Lee,Chi V. Dang +9 more
TL;DR: It is found that Myc binds the TFAM gene, which encodes a key transcriptional regulator and mitochondrial DNA replication factor, both in P493-6 lymphocytes with high ectopic MYC expression and in serum-stimulated primary human 2091 fibroblasts with induced endogenous MYC, which supports a pivotal role for Myc in regulating mitochondrial biogenesis.
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Transforming Growth Factor-β1 Induces an Epithelial-to-Mesenchymal Transition State in Mouse Hepatocytes in Vitro
TL;DR: It is shown that TGF-β1 induces an epithelial-to-mesenchymal transition (EMT) state in mature hepatocytes in vitro, and a potentially crucial role for EMT in the development and progression of hepatic fibrogenesis is supported.
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Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis
Amir Karban,Toshihiko Okazaki,Carolien I.M. Panhuysen,Thomas Gallegos,James J. Potter,Joan E. Bailey-Wilson,Mark S. Silverberg,Richard H. Duerr,Judy H. Cho,Peter K. Gregersen,Yuqiong Wu,Jean Paul Achkar,Themistocles Dassopoulos,Esteban Mezey,Theodore M. Bayless,Franklin J. Nouvet,Steven R. Brant +16 more
TL;DR: The first potentially functional polymorphism of NFKB1 is identified and its genetic association with a common human disease, ulcerative colitis is demonstrated.
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Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain
Anutosh Chakraborty,Michael A. Koldobskiy,Nicholas T. Bello,Micah J. Maxwell,James J. Potter,Krishna R. Juluri,David Maag,Seyun Kim,Alex S. Huang,Megan J. Dailey,Masoumeh Saleh,Adele M. Snowman,Timothy H. Moran,Esteban Mezey,Solomon H. Snyder +14 more
TL;DR: IP7 is a physiologic inhibitor of Akt, a serine/threonine kinase that regulates glucose homeostasis and protein translation, respectively, via the GSK3β and mTOR pathways and may afford a therapeutic approach to obesity and diabetes.
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Meta‐analysis: vitamin D and non‐alcoholic fatty liver disease
M. Eliades,E. Spyrou,N. Agrawal,Mariana Lazo,Frederick L. Brancati,James J. Potter,Ayman Koteish,Jeanne M. Clark,Eliseo Guallar,Ruben Hernaez +9 more
TL;DR: Non‐alcoholic fatty liver disease (NAFLD) is a highly prevalent condition and emerging evidence suggests that vitamin D may play a role in the pathogenesis of NAFLD.