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Esteban Mezey
Researcher at Johns Hopkins University School of Medicine
Publications - 177
Citations - 8306
Esteban Mezey is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Alcohol dehydrogenase & Hepatic stellate cell. The author has an hindex of 48, co-authored 176 publications receiving 7700 citations. Previous affiliations of Esteban Mezey include National Institutes of Health & Mount Sinai St. Luke's and Mount Sinai Roosevelt.
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Journal ArticleDOI
Corticosteroid therapy of alcoholic hepatitis
Willis C. Maddrey,John K. Boitnott,Marshall Bedine,Fredrick L. Weber,Esteban Mezey,Robert I. White +5 more
TL;DR: It is suggested that corticosteroid therapy does decrease early mortality in patients with severe alcoholic hepatitis, but has no short term effect on the development of portal hypertension.
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Transforming Growth Factor-β1 Induces an Epithelial-to-Mesenchymal Transition State in Mouse Hepatocytes in Vitro
TL;DR: It is shown that TGF-β1 induces an epithelial-to-mesenchymal transition (EMT) state in mature hepatocytes in vitro, and a potentially crucial role for EMT in the development and progression of hepatic fibrogenesis is supported.
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Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis
Amir Karban,Toshihiko Okazaki,Carolien I.M. Panhuysen,Thomas Gallegos,James J. Potter,Joan E. Bailey-Wilson,Mark S. Silverberg,Richard H. Duerr,Judy H. Cho,Peter K. Gregersen,Yuqiong Wu,Jean Paul Achkar,Themistocles Dassopoulos,Esteban Mezey,Theodore M. Bayless,Franklin J. Nouvet,Steven R. Brant +16 more
TL;DR: The first potentially functional polymorphism of NFKB1 is identified and its genetic association with a common human disease, ulcerative colitis is demonstrated.
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Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain
Anutosh Chakraborty,Michael A. Koldobskiy,Nicholas T. Bello,Micah J. Maxwell,James J. Potter,Krishna R. Juluri,David Maag,Seyun Kim,Alex S. Huang,Megan J. Dailey,Masoumeh Saleh,Adele M. Snowman,Timothy H. Moran,Esteban Mezey,Solomon H. Snyder +14 more
TL;DR: IP7 is a physiologic inhibitor of Akt, a serine/threonine kinase that regulates glucose homeostasis and protein translation, respectively, via the GSK3β and mTOR pathways and may afford a therapeutic approach to obesity and diabetes.
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Decreased Jejunal Uptake of Labeled Folic Acid (3H-PGA) in Alcoholic Patients: Roles of Alcohol and Nutrition
TL;DR: The data suggest that the functional defect is caused by poor nutrition rather than a toxic effect of ethanol on the jejunum, and confirms that the absorption of folic acid is decreased in malnourished, actively drinking alcoholics.