Ayub Mpoya

TL;DR: Excess mortality from boluses occurred in all subgroups of children and should prompt a re-evaluation of evidence on fluid resuscitation for shock and are-appraisal of the rate, composition and volume of resuscitation fluids.

TL;DR: Eight clinical prognostic factors that could be rapidly assessed by healthcare staff for triage were combined to create the FEAST Paediatric Emergency Triage (PET) score and externally validated and discriminated those at highest risk of fatal outcome at the point of hospital admission and compared well to other published risk scores.

TL;DR: There was no evidence of differences in clinical outcomes over 6 months between the children who received immediate transfusion and those who did not, and the triggered-transfusion strategy in the control group resulted in lower blood use; however, the length of hospital stay was longer, and this strategy required clinical and hemoglobin monitoring.

TL;DR: If confirmed by the trial, a cheap and widely available ‘bundle’ of effective interventions, directed at immediate and downstream consequences of severe anaemia, could lead to substantial reductions in mortality in a substantial number of African children hospitalised withsevere anaemia every year, if widely implemented.

TL;DR: Overall mortality did not differ between the two transfusion strategies, and there was no evidence of differences between the randomized groups in readmissions, serious adverse events, or hemoglobin recovery at 180 days.