A
Ayumu Sugiura
Researcher at Montreal Neurological Institute and Hospital
Publications - 22
Citations - 2339
Ayumu Sugiura is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Mitochondrion & Medicine. The author has an hindex of 13, co-authored 19 publications receiving 1759 citations. Previous affiliations of Ayumu Sugiura include Tokyo University of Pharmacy and Life Sciences & McGill University.
Papers
More filters
Journal ArticleDOI
A new pathway for mitochondrial quality control: mitochondrial‐derived vesicles
TL;DR: The Parkinson's disease‐associated proteins Vps35, Parkin, and PINK1 are involved in the biogenesis of a subset of these MDVs, linking this novel trafficking pathway to human disease.
Journal ArticleDOI
Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation
Diana Matheoud,Ayumu Sugiura,Angelique Bellemare-Pelletier,Annie Laplante,Christiane Rondeau,Magali Chemali,Ali Fazel,John J.M. Bergeron,Louis-Eric Trudeau,Yan Burelle,Etienne Gagnon,Heidi M. McBride,Michel Desjardins +12 more
TL;DR: A pathway for mitochondrial antigen presentation that relies on the generation and trafficking of mitochondrial-derived vesicles (MDVs) rather than on autophagy/mitophagy is demonstrated.
Journal ArticleDOI
Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes
TL;DR: It is shown that the essential import receptors Pex3 and Pex14 target mitochondria, where they are selectively released into vesicular pre-peroxisomal structures, thereby providing full import competence in newly born peroxisomes.
Journal ArticleDOI
MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death
TL;DR: It is demonstrated how interorganellar contacts are dynamically regulated through active SUMOylation during apoptosis, creating a stabilized platform that signals cytochrome c release.
Journal ArticleDOI
MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2.
Ayumu Sugiura,Shun Nagashima,Takeshi Tokuyama,Taku Amo,Yohei Matsuki,Satoshi Ishido,Yoshihisa Kudo,Heidi M. McBride,Toshifumi Fukuda,Nobuko Matsushita,Ryoko Inatome,Shigeru Yanagi +11 more
TL;DR: The mitochondrial ubiquitin ligase MITOL regulates mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) domain formation through mitofusin2 (Mfn2) through a specific interaction between MITOL C-terminal domain and Mfn2 HR1 domain, which is suggested to regulate ER tethering to mitochondria by activating Mfn 2 via K192 ubiquitination.