B.W. Barry

TL;DR: This review considers drug-vehicle interactions and the role of vesicles and particles and of particular interest is the synergy between chemical enhancers, ultrasound, iontophoresis and electroporation.

TL;DR: In this article, a general theory for skin penetration enhancer activity based on possible alterations at the molecular level of the stratum corneum was presented, where accelerants may interact at the polar head groups of the lipids, within aqueous regions between lipid head groups, and between the hydrophobic tails of the bilayer.

TL;DR: This article critically reviews the relevance of using different types of vesicles as a model for human skin in permeation enhancement studies, concentrating primarily on liposomes after briefly surveying older models.

TL;DR: Examples of accelerant action that support a general concept explaining enhancer activity in human skin, known as the lipid-protein-partitioning (LPP) concept are considered.

TL;DR: These concepts of Lipid-Protein-Partitioning theory of skin penetration enhancement are discussed, quoting examples of the three mechanisms as assessed by differential scanning calorimetry and permeation studies and relates such investigations to ideas of the molecular architecture of the stratum coraeum.