Journal ArticleDOI
Novel mechanisms and devices to enable successful transdermal drug delivery.
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TLDR
This review considers drug-vehicle interactions and the role of vesicles and particles and of particular interest is the synergy between chemical enhancers, ultrasound, iontophoresis and electroporation.About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-09-01. It has received 1143 citations till now. The article focuses on the topics: Drug delivery & Transdermal.read more
Citations
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Journal ArticleDOI
Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum
TL;DR: The progress and current status of the transdermal drug delivery field is detailed, numerous pharmaceutical developments which have been employed to overcome limitations associated with skin delivery systems are described and particular attention is paid to the emerging field of microneedle technologies.
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Dermal and transdermal drug delivery systems: Current and future prospects
TL;DR: For these novel delivery methods to succeed and compete with those already on the market, the prime issues that require consideration include device design and safety, efficacy, ease of handling, and cost-effectiveness.
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Ultrasonic Drug Delivery – A General Review
TL;DR: There remains a need to better understand the physics of cavitation of microbubbles and the impact that such cavitation has on cells and drug-carrying vesicle and makes cell membranes and capillaries more permeable to drugs.
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Lipid vesicles for skin delivery of drugs: Reviewing three decades of research
TL;DR: An overview of theDevelopment of lipid vesicles for skin delivery of drugs, with special emphasis on recent advances in this field, including the development of deformable liposomes and ethosomes is provided.
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Skin electroporation for transdermal and topical delivery
TL;DR: Molecular transport through transiently permeabilized skin by electroporation results mainly from enhanced diffusion and electrophoresis, and the efficacy of transport depends on the electrical parameters and the physicochemical properties of drugs.
References
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Book
Encyclopedia of Pharmaceutical Technology
TL;DR: Compounding, Contemporary, andProcess Chemistry in the Pharmaceutical Industry: Characterization and Function, Volume 19.
Journal ArticleDOI
Microfabricated microneedles: a novel approach to transdermal drug delivery.
TL;DR: These microneedle arrays could be easily inserted into skin without breaking and were shown to increase permeability of human skin in vitro to a model drug, calcein, by up to 4 orders of magnitude.
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Ethosomes — novel vesicular carriers for enhanced delivery: characterization and skin penetration properties
TL;DR: Experiments using fluorescent probes and ultracentrifugation showed that the ethosomes had a high entrapment capacity for molecules of various lyophilicities, including testosterone from an ethosomal patch was greater both in vitro and in vivo than from commercially available patches.
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A controlled-release microchip
TL;DR: A solid-state silicon microchip that can provide controlled release of single or multiple chemical substances on demand is reported, based on the electrochemical dissolution of thin anode membranes covering microreservoirs filled with chemicals in solid, liquid or gel form.
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Ultrasound-mediated transdermal protein delivery.
TL;DR: Low-frequency ultrasound was shown to increase the permeability of human skin to many drugs, including high molecular weight proteins, by several orders of magnitude, thus making transdermal administration of these molecules potentially feasible.