Journal ArticleDOI
Lipid-Protein-Partitioning theory of skin penetration enhancement
TLDR
These concepts of Lipid-Protein-Partitioning theory of skin penetration enhancement are discussed, quoting examples of the three mechanisms as assessed by differential scanning calorimetry and permeation studies and relates such investigations to ideas of the molecular architecture of the stratum coraeum.About:
This article is published in Journal of Controlled Release.The article was published on 1991-06-01. It has received 274 citations till now.read more
Citations
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Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review.
TL;DR: The possible role and mode of action of these natural products is discussed with regard to the prevention and treatment of cancer, cardiovascular diseases including atherosclerosis and thrombosis, as well as their bioactivity as antibacterial, antiviral, antioxidants and antidiabetic agents.
Journal ArticleDOI
Novel mechanisms and devices to enable successful transdermal drug delivery.
TL;DR: This review considers drug-vehicle interactions and the role of vesicles and particles and of particular interest is the synergy between chemical enhancers, ultrasound, iontophoresis and electroporation.
Journal ArticleDOI
Coherent Anti-Stokes Raman Scattering Microscopy: Chemical Imaging for Biology and Medicine
Conor L. Evans,X. Sunney Xie +1 more
TL;DR: Coherent anti-Stokes Raman scattering (CARS) microscopy is a label-free imaging technique that is capable of real-time, nonperturbative examination of living cells and organisms based on molecular vibrational spectroscopy.
Journal ArticleDOI
Liposomes and skin: from drug delivery to model membranes.
TL;DR: This article critically reviews the relevance of using different types of vesicles as a model for human skin in permeation enhancement studies, concentrating primarily on liposomes after briefly surveying older models.
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Challenges and opportunities in dermal/transdermal delivery
Kalpana S. Paudel,Mikolaj Milewski,Courtney L. Swadley,Nicole K. Brogden,Priyanka Ghosh,Audra L. Stinchcomb +5 more
TL;DR: Emergence of novel techniques for skin permeation enhancement and development of methods to lessen skin irritation would widen the transdermal market for hydrophilic compounds, macromolecules and conventional drugs for new therapeutic indications.
References
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Journal ArticleDOI
Mode of action of penetration enhancers in human skin
TL;DR: In this article, a general theory for skin penetration enhancer activity based on possible alterations at the molecular level of the stratum corneum was presented, where accelerants may interact at the polar head groups of the lipids, within aqueous regions between lipid head groups, and between the hydrophobic tails of the bilayer.
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Human stratum corneum lipids: characterization and regional variations.
Lampe Ma,Alma L. Burlingame,Joanne D. Whitney,Mary L. Williams,Barbara E. Brown,Esther Roitman,Peter M. Elias +6 more
TL;DR: The first detailed, quantitative analysis of human stratum corneum lipids and information about the variability in lipid composition at four skin sites with known differences in permeability suggest that variations in neutral lipids, rather than sphingolipids, may underlie local variations in skin permeability.
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Human epidermal lipids: characterization and modulations during differentiation.
TL;DR: These studies: 1) provide new quantitative data about human epidermal lipids; 2) implicate certain classes of lipids for specific functions of the stratum corneum; and, 3) shed light on possible product-precursor relationships of these lipids.
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Structure of lamellar lipid domains and corneocyte envelopes of murine stratum corneum. An X-ray diffraction study
TL;DR: By X-ray diffraction, the structure of the intercellular domains and the extracted lipids of murine stratum corneum and the protein envelopes of the corneocytes are surveyed, and patterns suggest a beta-pleated sheet organizational scheme.