2. Essential Components: Earlier Developments 5449 2.1. Activated alkenes/alkynes 5450 2.1.1. Acyclic activated alkenes/ alkynes 5450 2.1.2. Cyclic activated alkenes 5451 2.2. Electrophiles 5451 2.3. Catalysts 5452 3. Essential Components: Recent Developments 5452 3.1. Activated Alkenes/Alkynes 5452 3.2. Electrophiles 5460 3.3. Catalysts 5477 4. Asymmetric Baylis-Hillman Reaction: Earlier Developments 5495

Recent contributions from the Baylis-Hillman reaction to organic chemistry.

This tutorial review highlights the way in which the Baylis–Hillman reaction has been increasingly attracting the attention of synthetic and medicinal chemists; it not only helps in originating new ideas to create novel methodologies and molecules but also offers intellectual challenges to understand and address the present day needs in the areas of organic and medicinal chemistry.

http://www.chtf.stuba.sk/~szolcsanyi/education/files/Chemia%20heterocyklickych%20zlucenin/Prednaska%204/Doplnkove%20studijne%20materialy/Morita_Baylis_Hillman%20reaction/The%20Baylis%96Hillman%20reaction%20-%20a%20novel%20concept%20for%20creativity%20in%20chemistry.pdf

The Baylis–Hillman reaction: a novel concept for creativity in chemistry

Recent progress in synthesis and bioactivity studies of indolizines.

A copper-catalyzed method for the synthesis of imidazo[1,2-a]pyridines with aminopyridines and nitroolefins using air as oxidation agent in a one-pot procedure has been developed. In this process, the reaction appears to be very general and suitable for construction of a variety of imidazo[1,2-a]pyridines.

Cu(I)-catalyzed synthesis of imidazo[1,2-a]pyridines from aminopyridines and nitroolefins using air as the oxidant.

Visible light mediated azomethine ylide formation—photoredox catalyzed [3+2] cycloadditions

A facile one-pot synthesis of indolizine, benzofused indolizines {pyrrolo[1,2-a]quinoline and pyrrolo[1,2-a]isoquinoline} derivatives from the Baylis-Hillman (B-H) bromides, via an interesting strategy involving 1,5-cyclization of nitrogen ylides has been described.

The Baylis-HillmanBromides as Versatile Synthons: A Facile One-Pot Synthesisof Indolizine and Benzofused Indolizine Frameworks

Unsymmetrical, disubstituted maleimide and maleic anhydride frameworks have been accessed from Baylis-Hillman adducts in an operationally simple three-step (Friedel-Crafts reaction, selective hydrolysis, and cyclization), one-pot strategy. This strategy has been successfully extended to the synthesis of a representative bioactive compound, himanimide A.

A facile one-pot transformation of Baylis-Hillman adducts into unsymmetrical disubstituted maleimide and maleic anhydride frameworks: a facile synthesis of himanimide A.

Badugu Devendar

Papers

The Baylis-HillmanBromides as Versatile Synthons: A Facile One-Pot Synthesisof Indolizine and Benzofused Indolizine Frameworks

A facile one-pot transformation of Baylis-Hillman adducts into unsymmetrical disubstituted maleimide and maleic anhydride frameworks: a facile synthesis of himanimide A.

A simple protocol for the synthesis of a piperidine-2,6-dione framework from Baylis―Hillman adducts

Ring rearrangement metathesis of 2-allylbicyclo[2.2.2]octenes: a short entry to cis-hydrindenols from 2-methoxyphenols

The Baylis—Hillman Bromides as Versatile Synthons: A Facile One-Pot Synthesis of Indolizine and Benzofused Indolizine Frameworks.