B
Bahige M. Baroudy
Researcher at Schering-Plough
Publications - 62
Citations - 5036
Bahige M. Baroudy is an academic researcher from Schering-Plough. The author has contributed to research in topics: Virus & CCR5 receptor antagonist. The author has an hindex of 34, co-authored 62 publications receiving 4966 citations. Previous affiliations of Bahige M. Baroudy include Massachusetts Institute of Technology & National Institutes of Health.
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Journal ArticleDOI
Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses.
TL;DR: HAV proteins are less homologous with those of any other picornavirus than the latter proteins are when compared with each other, and when the sequences of wild-type and cell culture-adapted HAV strains are compared, the nucleotide Differences in the 5' noncoding region and the amino acid differences in the capsid region suggest areas that may contain markers for cell culture adaptation and for attenuation.
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SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo.
Julie M. Strizki,Serena Xu,Nicole Wagner,Lisa Wojcik,Jia Liu,Yan Hou,Matthias Endres,Anandan Palani,Sherry Shapiro,John W. Clader,William J. Greenlee,Jayaram R. Tagat,Stuart W. McCombie,Kathleen Cox,Ahmad Fawzi,Chuan-Chu Chou,Catherine Pugliese-Sivo,Liza Davies,Mary E. Moreno,David D. Ho,Alexandra Trkola,Cheryl A. Stoddart,John P. Moore,Gregory R. Reyes,Bahige M. Baroudy +24 more
TL;DR: SCH-C has broad and potent antiviral activity in vitro against primary HIV-1 isolates that use CCR5 as their entry coreceptor, with mean 50% inhibitory concentrations ranging between 0.4 and 9 nM.
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HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use
Alexandra Trkola,Shawn E. Kuhmann,Julie M. Strizki,Elizabeth S. Maxwell,Tom Ketas,Thomas Hunt Morgan,Pavel Pugach,Serena Xu,Lisa Wojcik,Jayaram R. Tagat,Anandan Palani,Sherry Shapiro,John W. Clader,Stuart W. McCombie,Gregory R. Reyes,Bahige M. Baroudy,John P. Moore +16 more
TL;DR: HIV-1 acquires the ability to use CCR5 despite the inhibitor, first by requiring lower levels of C CR5 for entry and then probably by using the drug-bound form of the receptor.
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Characterization of Soluble Hepatitis C Virus RNA-Dependent RNA Polymerase Expressed in Escherichia coli
Eric Ferrari,Jacquelyn Wright-Minogue,Jane W. S. Fang,Bahige M. Baroudy,Johnson Y. N. Lau,Zhi Hong +5 more
TL;DR: Fine deletional analysis of this region revealed that a four-leucine motif (LLLL) in the hydrophobic domain is responsible for the solubility profile of the full-length NS5B.
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Incompletely base-paired flip-flop terminal loops link the two DNA strands of the vaccinia virus genome into one uninterrupted polynucleotide chain
TL;DR: Self-priming and de novo start replication models, which involve a site-specific nick in one DNA strand proximal to the 104 nucleotide loop, account for the observed sequence inversions and incomplete base-pairing.