Matthew R. Rosengart

TL;DR: Results demonstrate that hypoxia-induced HMGB1 release by hepatocytes is an active, regulated process that occurs through a mechanism promoted by TLR4-dependent ROS production and downstream CaMK-mediated signaling.

TL;DR: In injured patients at risk for hemorrhagic shock, the prehospital administration of thawed plasma was safe and resulted in lower 30‐day mortality and a lower median prothrombin‐time ratio than standard‐care resuscitation.

TL;DR: This guideline summarizes the current recommendations developed by the SIS task force on the treatment of patients who have IAI regarding risk assessment in individual patients; source control; the timing, selection, and duration of antimicrobial therapy; and suggested approaches to patients who fail initial therapy.

TL;DR: In patients requiring>/=8 units of blood after serious blunt injury, an FFP:PRBC transfusion ratio >/=1:1.5 was associated with a significant lower risk of mortality but a higher risk of acute respiratory distress syndrome, providing further justification for the prospective trial investigation into the optimal FFP-PRBC ratio required in massive transfusion practice.

TL;DR: In patients who survive their initial injury, FFP was independentlyassociated with a greater risk of developing MOF and ARDS, whereas CRYO was associated with a lower risk of MOF.