B
Bakhtiar Yamini
Researcher at University of Chicago
Publications - 67
Citations - 1480
Bakhtiar Yamini is an academic researcher from University of Chicago. The author has contributed to research in topics: Medicine & DNA damage. The author has an hindex of 19, co-authored 56 publications receiving 1104 citations. Previous affiliations of Bakhtiar Yamini include University of Illinois at Chicago.
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Journal ArticleDOI
Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial.
E. Antonio Chiocca,E. Antonio Chiocca,John S. Yu,Rimas V. Lukas,Rimas V. Lukas,Isaac H. Solomon,Keith L. Ligon,Hiroshi Nakashima,Daniel Triggs,David A. Reardon,Patrick Y. Wen,Brittany M. Stopa,Ajay Naik,Jeremy Rudnick,Jethro Hu,Priya Kumthekar,Bakhtiar Yamini,Jill Buck,Nathan Demars,John A. Barrett,Arnold Gelb,John Zhou,Francois Lebel,Laurence J.N. Cooper,Laurence J.N. Cooper +24 more
TL;DR: This phase 1 trial showed acceptable tolerability of regulated hIL-12 with encouraging preliminary results, and inflammatory infiltrates in patients undergoing resection of recurrent high-grade glioma support an immunological antitumor effect of h IL-12.
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Initial endoscopic management of pineal region tumors and associated hydrocephalus: clinical series and literature review.
TL;DR: The authors conclude that the endoscopic management of patients with pineal region masses and hydrocephalus may be a preferred initial strategy.
Journal ArticleDOI
Nuclear factor-κB in glioblastoma: insights into regulators and targeted therapy.
TL;DR: The importance of this transcription factor in the overall malignant phenotype suggests that more rational and specific targeting of NF-κB-dependent pathways can make a significant contribution to the management of GBM.
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Convection-enhanced delivery and in vivo imaging of polymeric nanoparticles for the treatment of malignant glioma.
Giovanna M. Bernal,Michael J. LaRiviere,Nassir Mansour,Peter Pytel,Kirk E. Cahill,David J. Voce,Shijun Kang,Ruben Spretz,Ulrich Welp,Sandra Noriega,Luis Nunez,Gustavo Larsen,Ralph R. Weichselbaum,Bakhtiar Yamini +13 more
TL;DR: In this article, a polymeric nanoparticle vector that not only delivers viable therapeutic, but can also be tracked in vivo using MRI was described, which can be used for image-guided treatment of malignant glioma.
Journal ArticleDOI
Loss of Nfkb1 leads to early onset aging
Giovanna M. Bernal,Joshua S. Wahlstrom,Clayton D. Crawley,Kirk E. Cahill,Peter Pytel,Hua Liang,Shijun Kang,Ralph R. Weichselbaum,Bakhtiar Yamini +8 more
TL;DR: Data show that loss of Nfkb1 leads to early animal aging that is associated with reduced apoptosis and increased cellular senescence, and support the strong link between the NF-(B pathway and mammalian aging.