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Baoxue Yang
Researcher at Peking University
Publications - 179
Citations - 8840
Baoxue Yang is an academic researcher from Peking University. The author has contributed to research in topics: Urea transporter & Kidney. The author has an hindex of 48, co-authored 151 publications receiving 8013 citations. Previous affiliations of Baoxue Yang include Jilin University & University of California, San Francisco.
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Journal ArticleDOI
Severely Impaired Urinary Concentrating Ability in Transgenic Mice Lacking Aquaporin-1 Water Channels
Tonghui Ma,Baoxue Yang,Annemarie Gillespie,Elaine J. Carlson,Charles J. Epstein,Alan S. Verkman +5 more
TL;DR: The results suggest that AQP1 knockout mice are unable to create a hypertonic medullary interstitium by countercurrent multiplication, and AQP 1 is thus required for the formation of a concentrated urine by the kidney.
Journal ArticleDOI
Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4.
Tonghui Ma,Baoxue Yang,Annemarie Gillespie,Elaine J. Carlson,Charles J. Epstein,Alan S. Verkman +5 more
TL;DR: The results indicate that AQP4 deletion in CD1 mice has little or no effect on development, survival, growth, and neuromuscular function, but produces a small defect in urinary concentrating ability consistent with its expression in the medullary collecting duct.
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Water and glycerol permeabilities of aquaporins 1-5 and MIP determined quantitatively by expression of epitope-tagged constructs in Xenopus oocytes.
Baoxue Yang,Alan S. Verkman +1 more
TL;DR: Compared single channel water and glycerol permeabilities of mammalian aquaporins (AQP) 1–5 and the major intrinsic protein of lens fiber (MIP) are indicated, with the p f value for AQP4 remarkably higher than those for the others.
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Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels
Tonghui Ma,Yuanlin Song,Baoxue Yang,Annemarie Gillespie,Elaine J. Carlson,Charles J. Epstein,Alan S. Verkman +6 more
TL;DR: Aquaporin-3 deletion is established as a form of nephrogenic diabetes insipidus produced by impaired water permeability in collecting-duct basolateral membrane and may provide blood-accessible targets for drug discovery of aquaretic inhibitors.
Journal ArticleDOI
The Mercurial Insensitive Water Channel (AQP-4) Forms Orthogonal Arrays in Stably Transfected Chinese Hamster Ovary Cells
TL;DR: Results provide direct evidence that a molecular water channel can spontaneously assemble in regular arrays.