D
Dennis Brown
Researcher at Harvard University
Publications - 531
Citations - 37395
Dennis Brown is an academic researcher from Harvard University. The author has contributed to research in topics: Sindbis virus & Apical membrane. The author has an hindex of 98, co-authored 519 publications receiving 34509 citations. Previous affiliations of Dennis Brown include Tufts Medical Center & North Carolina State University.
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Journal ArticleDOI
Cellular uptake of nanoparticles: journey inside the cell.
Shahed Behzadi,Vahid Serpooshan,Wei Tao,Majd A. Hamaly,Mahmoud Y. Alkawareek,Erik C. Dreaden,Dennis Brown,Alaaldin M. Alkilany,Omid C. Farokhzad,Omid C. Farokhzad,Morteza Mahmoudi,Morteza Mahmoudi +11 more
TL;DR: This review provides an objective and comprehensive account of the cellular uptake of NPs and the underlying parameters controlling the nano-cellular interactions, along with the available analytical techniques to follow and track these processes.
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TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.
Jochen Reiser,Krishna R. Polu,Clemens C. Möller,Peter Kenlan,Mehmet M. Altintas,Changli Wei,Christian Faul,Stephanie Herbert,Ivan Villegas,Carmen Avila-Casado,Mary McGee,Hikaru Sugimoto,Dennis Brown,Raghu Kalluri,Peter Mundel,Paula Smith,David E. Clapham,Martin R. Pollak +17 more
TL;DR: It is shown that the canonical transient receptor potential 6 (TRPC6) ion channel is expressed in podocytes and is a component of the glomerular slit diaphragm.
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Macrophages facilitate electrical conduction in the heart
Maarten Hulsmans,Sebastian Clauss,Sebastian Clauss,Ling Xiao,Aaron D. Aguirre,Kevin R. King,Alan Hanley,Alan Hanley,William J. Hucker,Eike M. Wülfers,Gunnar Seemann,Gabriel Courties,Yoshiko Iwamoto,Yuan Sun,Andrej J. Savol,Hendrik B. Sager,Kory J. Lavine,Gregory A. Fishbein,Diane E. Capen,Nicolas Da Silva,Lucile Miquerol,Hiroko Wakimoto,Christine E. Seidman,Christine E. Seidman,Jonathan G. Seidman,Ruslan I. Sadreyev,Kamila Naxerova,Richard N. Mitchell,Dennis Brown,Peter Libby,Ralph Weissleder,Filip K. Swirski,Peter Kohl,Claudio Vinegoni,David J. Milan,David J. Milan,Patrick T. Ellinor,Patrick T. Ellinor,Matthias Nahrendorf +38 more
TL;DR: It is shown that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely intersperse with elongated macrophage expressing connexin 43.
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The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose.
TL;DR: The characterization of a previously cloned human kidney cDNA that codes for a protein with 59% identity to the high affinity Na+/glucose cotransporter (SGLT1) is reported, and it is demonstrated that this protein (termed SGLT2) mediates saturable Na(+)-dependent and phlorizin-sensitive transport of D-glugose and alpha-methyl-D-glucopyranoside
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Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells.
TL;DR: The temporal and nephron segment expressions of various proteins implicated in mitogenesis, differentiation, and injury support the view that the mature renal S3 segment epithelial cell can be a progenitor cell.