Barbara C. Furie

TL;DR: Compared fibrin generation and platelet thrombus formation between mice lacking tissue factor in either the intravascular or the extravascular compartment using the laser injury model of thrombosis in the mouse cremaster muscle concludes that when endothelial disruption is minimized, intrav vascular TF plays a significant role in fibr in formation, while smooth muscle cell derived TF does not.

TL;DR: This work has determined if endothelial cells are activated in response to the injury induced by a pulsed laser, and indicates the presence of a preformed intracellular pool of TF within HUVECs that under resting conditions is not detectable on the cell surface.

TL;DR: The combined results demonstrate that extracellular PDI regulates vitronectin in a growing thrombus to promote platelet accumulation and fibrin generation and suggest that plasma-derived vitronctin and not platelet- derived vitronECTin is the primary substrate of PDI.

TL;DR: In this article, a B-domain deleted human Factor VIII and its three-dimensional structure were provided, and methods for identifying compounds that modulate Factor VIII activity, for determining structures of Factor VIII homologs or analogs, and for designing drug candidates for the treatment of hemophilia based on the structural information.

TL;DR: It is demonstrated using intravital microscopy that purified anti- beta-2 glycoprotein 1 antibodies isolated from the serum of a patient with APS greatly amplify thrombus size following laser-induced vessel wall injury in live mice, providing evidence that anti-beta- 2 glycop protein 1 antibodies are not only a marker but are directly involved in the pathogenesis of thrombosis.