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Barbara C. Furie
Researcher at Beth Israel Deaconess Medical Center
Publications - 135
Citations - 9851
Barbara C. Furie is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Thrombus & Platelet. The author has an hindex of 49, co-authored 135 publications receiving 9397 citations. Previous affiliations of Barbara C. Furie include Harvard University & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
A critical role for extracellular protein disulfide isomerase during thrombus formation in mice
TL;DR: PDI is required in vivo in mice for both fibrin generation and platelet thrombus formation, and there is no stable accumulation of platelets in mice lacking the G protein-coupled platelets.
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Platelet-derived microparticles express high affinity receptors for factor VIII.
Gary E. Gilbert,Peter J. Sims,Therese Wiedmer,Bruce Furie,Barbara C. Furie,Sanford J. Shattil +5 more
TL;DR: These studies indicate that activated platelets express a transient increase in high affinity receptors for factor VIII, whereas platelet-derived microparticles express a sustained increase in receptors.
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Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation.
Bruce Furie,Barbara C. Furie +1 more
TL;DR: Findings have demonstrated that leukocyte-derived microparticles circulate in the blood and accumulate in the developing platelet-rich thrombus following vessel wall injury, thus concentrating tissue factor at the site of vascular injury and initiating blood coagulation.
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Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex
TL;DR: The X-ray crystal structure of B domain-deleted human factor VIII was determined and a model of the factor IXa-factor VIIIa complex was constructed by in silico docking to provide insight into the activation of factor VIII and the interaction of factor VIIa with factor VIIIa on the membrane surface.
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Glycoprotein VI-dependent and -Independent Pathways of Thrombus Formation in Vivo
Christophe Dubois,Laurence Panicot-Dubois,Laurence Panicot-Dubois,Glenn Merrill-Skoloff,Glenn Merrill-Skoloff,Bruce Furie,Bruce Furie,Barbara C. Furie,Barbara C. Furie +8 more
TL;DR: Platelet activation by thrombin appears to be more important after laser injury than plateletactivation by GPVI-collagen, and it may be important when considering targets for antithrombotic therapy to use multiple animal models with diverse pathways to thrombus formation.