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Barbara D. Abbott
Researcher at Research Triangle Park
Publications - 79
Citations - 6142
Barbara D. Abbott is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Developmental toxicity & Receptor. The author has an hindex of 40, co-authored 79 publications receiving 5600 citations. Previous affiliations of Barbara D. Abbott include United States Environmental Protection Agency.
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Rapid distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to embryonic tissues in C57BL/6N mice and correlation with palatal uptake in vitro.
TL;DR: The present study is the first to allow a direct comparison of the level of TCDD in embryonic tissue after in vivo and in vitro exposures and shows that the palatal organ culture model provides a reasonable dosimetric representation of in utero exposure.
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2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) disrupts early morphogenetic events that form the lower reproductive tract in female rat fetuses.
TL;DR: The objective of the current study was to determine the earliest time after exposure to TCDD during fetal development that morphological changes in the development of the lower reproductive tract could be detected and the spatio-temporal expression of several growth factors within the developing reproductive tract was investigated to provide insight into the mechanism of action involved in T CDD-induced vaginal thread formation.
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Cell death in rat and mouse embryos exposed to methanol in whole embryo culture
TL;DR: The results of this study suggest that increased cell death in specific regions of the exposed embryos has a role in producing cranial malformations, abnormalities of the eye and ear, and cleft palate.
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Teratogenic effects of retinoic acid are modulated in mice lacking expression of epidermal growth factor and transforming growth factor‐α
TL;DR: A role for EGF and TGFalpha in the response to RA is supported and skeletal and visceral defects in all genotypes are produced; however, EGF or TGF alpha KO influenced the incidence and severity of defects.
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Adrenocorticotropin (ACTH) and corticosterone secretion by perifused pituitary and adrenal glands from rodents exposed to 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD).
TL;DR: In this article, the effects of chemically-induced alterations of the maternal hypothalamic-pituitary-adrenal axis (HPA) have not been well studied, although in utero maternal stress has been shown to have lasting effects on rodent offspring.