Barbara D. Abbott

TL;DR: Estimates of hepatic half-life of elimination in pregnant rats suggested that TCDD may be eliminated faster in pregnant LE rats, and measurements of biliary elimination were made in pregnant and nonpregnant LE rats to compare rates of metabolism; however, biliary removal is not affected by pregnancy.

TL;DR: The pattern was similar in human hepatocytes, although PFDA and PFOS showed higher activity than previously observed while PFOA showed somewhat less activity, and little consistency was observed across compounds with respect to which genes produced a significant dose response making the determination of relative biological activity difficult.

TL;DR: EGF and TGF-alpha expression are important for the formation of ADLBs and VBs, and expression of EGF andTGF- alpha affects the ability of TCDD to inhibit prostatic bud formation in a region-specific manner.

TL;DR: It is concluded that progressive inhibition of proliferation and growth in organ culture results in two different morphological outcomes: cleft palate resulting from a narrowed oral cavity and increased incidence of anterior palatal fusion under conditions of strong growth reduction.

TL;DR: Dose-dependent deficits in metatarsal and phalanx development were observed in hindlimb explants dissected either 3 or 6 hr after maternal treatment, and defects of palatal fusion at the end of the culture period were similar to those in craniofacial tissues that continued to develop in utero after treatment.